2022年6月22日 · Here we present a high-resolution cryo-electron microscopy (cryo-EM) structure of a 2.8 megadalton T4SS complex composed of 92 polypeptides representing 8 of the 10 …

2024年4月3日 · Here we discuss how the interplay between cryo-EM and cryo-electron tomography, as a connecting bridge to visualize macromolecules in situ, holds great promise …

2022年5月13日 · Here, we report the cryo-EM structures of human GLUT4 bound to a small molecule inhibitor cytochalasin B (CCB) at resolutions of 3.3 Å in both detergent micelles and …

The 3.8Å cryo-EM structure of the mature Zika virus revealed the arrangement of 180 envelope glycoproteins forming the icosahedral shell and highlighted unique features near the Asn154 …

2022年1月20日 · This review summarizes the current state of methods and results achievable by cryo-electron microscopy (cryo-EM) imaging for molecular, cell, and structural biologists who …

In this article, the principle, characteristics, history, current situation, workflow, and common problems of cryo‐EM are systematically reviewed. In addition, the new development direction …

4 天之前 · Our cryo-EM structure supported the previous prediction from cross-linking and structural analyses that the polypeptide ligand interacts with the edge strand of the MREβ …

Here, we present the cryo–electron microscopy structure of the outward open conformation of the rat peptide transporter PepT2 in complex with an inhibitory nanobody.

2024年1月24日 · Here, we report the cryogenic electron microscopy (cryo-EM) structure of an active PR, specifically the complete, heterodimeric TPR apoenzyme determined at its optimal …

Cryo-EM plays an important role in revealing the structures underlying these processes. For example, the Kirchdoerfer group used cryo-EM to reconstruct the polymerase of an …