Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor ...

c-Jun, the most extensively studied protein of the activator protein-1 (AP-1) complex, is involved in numerous cell activities, such as proliferation, apoptosis, survival, tumorigenesis and tissue morphogenesis. Earlier studies focused on the structure and function have led to …

摘要：C-jun是一种即早基因，其表达受到c-jun的N-末端激酶(JNK)的调控。 C-jun和JNK信号通路作为创伤、应激、 细胞增殖与凋亡相关的调节因子，参与调节多种肝脏应激与损伤的过程。

c-jun 蛋白是属于活化蛋白-1（ap-1）转录复合物中的一种，是ap-1复合物中zui具有转录活性的转录因子，各种物理、化学、生物学刺激及细胞应激反应都可以通过促进c-jun 蛋白表达活化，进而对细胞增殖、凋亡等生物学…

2019年12月4日 · Here we show that CAR T cells engineered to overexpress the canonical AP-1 factor c-Jun have enhanced expansion potential, increased functional capacity, diminished terminal differentiation and...

The c–jun gene is normally relatively weakly expressed in myocytes, but c–jun mRNA and c–Jun protein are rapidly and transiently induced by ET-1, and it is possible that this is important in the development of the hypertrophic phenotype.

We show that in fibroblasts, c-Jun is required for progression through the G1 phase of the cell cycle; c-Jun-mediated G1 progression occurs by a mechanism that involves direct transcriptional control of the cyclin D1 gene, establishing a molecular link between growth factor signaling and cell cycle regulators.

2011年12月17日 · c-Jun, the most extensively studied protein of the activator protein-1 (AP-1) complex, is involved in numerous cell activities, such as proliferation, apoptosis, survival, tumorigenesis and tissue morphogenesis.

c-Jun是转录因子AP-1的组成部分，可被多种细胞外刺激激活。c-Jun的调节很复杂，既涉及c-Jun蛋白水平的提高，又包括Jun N-末端激酶（JNK）对特定丝氨酸（63和73）的磷酸化作用。

c-Jun is a major component of the dimeric transcription factor activator protein-1 (AP-1), a paradigm for transcriptional response to extracellular signaling, whose components are basic-Leucine Zipper (bZIP) transcription factors of the Jun, Fos, activating transcription factor (ATF), ATF-like (BATF) and Jun dimerization protein 2 (JDP2) gene ...