All Rh(D) negative women (who have not actively formed their own Anti-D) should be offered a prophylactic dose of 625 IU at approximately 28 weeks gestation and again at approximately 34 weeks gestation.

During pregnancy, a Rhesus negative (Rh‐negative) woman may develop antibodies when her fetus is Rhesus positive (Rh‐positive). These antibodies may harm Rh‐positive babies. To assess the effects of antenatal anti‐D immunoglobulin on the incidence of Rhesus D alloimmunisation when given to Rh‐negative women without anti‐D antibodies.

RAADP is recommended for all pregnant RhD negative women who haven't been sensitised to the RhD antigen, even if you previously had an injection of anti-D immunoglobulin. As RAADP doesn't offer lifelong protection against rhesus disease, it will be offered every time you become pregnant if you meet these criteria.

The objective of this guideline is to provide healthcare professionals with practical guidance on the use of anti-D Ig as immunoprophylaxis to prevent sensitisation to the D antigen during pregnancy or at delivery for the prevention of HDN.

Anti-D is only needed if an RhD negative woman or person is pregnant with an RhD positive baby. In about one in three pregnancies, the baby will be RhD negative and an anti-D injection would therefore not be necessary.

For a multiple pregnancy, the dose of Anti-D Immunoglobulin should be increased to 625 IU. Anti-D should be offered and administered within 72 hours of any event listed above. Kleihauer testing is not required before 20 weeks gestation. The standard dose of Anti-D Immunoglobulin is 625 IU, administered within 72 hours.

2015年9月3日 · Selection criteria: Randomised trials in Rh-negative women without anti-D antibodies given anti-D after 28 weeks of pregnancy, compared with no treatment, placebo or a different regimen of anti-D. Data collection and analysis: Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for ...

• Administration of anti-D immunoglobulin at approximately 28 and 34 weeks during pregnancy to Rh(D) negative wāhine who have not actively formed their own anti-D results in a reduction of sensitisation from about 1% to 0.3%

Anti-D prophylaxis means giving anti-D immunoglobulin to prevent a woman producing antibodies against rhesus positive blood cells and so to prevent the development of HDN in an unborn baby. Anti-D immunoglobulin is made from a part of the blood called plasma that is collected from donors. When do I need anti-D prophylaxis?

Anti-D should be considered if there is heavy or repeated bleeding or associated abdominal pain as gestation approaches 12+0 weeks. Gestational age should be confirmed by ultrasound. After 12+0 weeks – 250 IU Anti-D Ig should be given to all non-sensitised RhD negative women with a threatened miscarriage.