Acyl-CoA is a group of CoA-based coenzymes that metabolize carboxylic acids. Fatty acyl-CoA 's are susceptible to beta oxidation , forming, ultimately, acetyl-CoA . The acetyl-CoA enters the …

脂肪酸的活化反应在胞液中进行，脂肪酸在脂酰CoA 合成酶 （acyl-CoA synthetase）催化下，在ATP、 CoA-SH 、Mg存在的条件下，活化为脂酰CoA。脂酰CoA含有高能硫酯键，而且水溶 …

Long-chain fatty acyl-coenzyme As (CoAs) are critical regulatory molecules and metabolic intermediates. The initial step in their synthesis is the activation of fatty acids by one of 13 long …

Acyl-CoA synthetases, also known as acyl-CoA ligases, are enzymes that “activate” fatty acids by thioesterification to coenzyme A. [1] It represents the initial step of fatty acid metabolism so …

Generated acyl-CoA as a raw material initiates the subsequent metabolism pathway to produce energy or synthesize diverse complex lipids. In addition, acyl-CoA can be deactivated to free …

脂酰CoA合成酶（acyl-CoA synthetase）催化脂肪酸活化反应。 脂肪酸在氧化分解前，必须先转变为活泼的脂酰CoA。 该酶在ATP、CoASH、Mg2+参与下，催化脂肪酸活化形成脂酰CoA。

Acetyl-CoA, a prototypical acyl-CoA, is the product of several catabolic processes in the mitochondria, whereas in the cytosol, it is the primary substrate for anabolic processes, …

2024年9月24日 · The major acyl donor, acyl-CoA, enables modifications that impart distinct biological functions to both histone and non-histone proteins. These modifications are crucial …

Acyl-CoA formation initiates cellular fatty acid metabolism. Acyl-CoAs are generated by the ligation of a fatty acid to Coenzyme A mediated by a large family of acyl-CoA synthetases …

2024年6月13日 · The total cellular CoA pool primarily consists of free (unesterified/unacylated) CoA and a diverse array of acylated species (acyl-CoAs) including acetyl-CoA and succinyl …