2019年1月7日 · Left-handed Z-DNA/Z-RNA is bound with high affinity by the Zα domain protein family that includes ADAR (a double-stranded RNA editing enzyme), ZBP1 and viral orthologs regulating innate immunity.

Z-RNA to resemble, but not be identical, to that of Z-DNA. [2] The structure of the complex of a Zalpha domain with Z-RNA under close to physiological salt concentrations however suggests a structure much closer to the Z-DNA conformation and points to two forms of Z-RNA (low and high salt conformations) [3]

2020年3月19日 · Influenza A virus (IAV) is a lytic RNA virus that triggers receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated pathways of apoptosis and mixed lineage kinase domain-like pseudokinase (MLKL)-dependent necroptosis in infected cells. ZBP1 initiates RIPK3-driven cell death by sensing …

撰稿 | 王识博博士 . 审校 | 蔡志坚 教授 文献概述. 01 研究背景介绍：. 甲型流感病毒（iav）是正粘病毒科的 单股负链rna病毒 （ssrna），ss-rna与核蛋白 (np)相结合，缠绕成核糖核蛋白体 (rnp)，以密度极高的形式存在。 甲型流感病毒的rna由8个节段组成，第1、2、3个节段编码的是rna多聚集酶，第4个节段 ...

2021年1月11日 · Defective binding of Z-RNA to ADAR1 exclusively activated the MDA5–mitochondrial antiviral-signalling protein (MAVS) pathway, leading to spontaneous type I interferon production in both a human ...

nature：揭示z型核酸触发zbp1依赖性的坏死性凋亡和炎症. ripk1; z-dna; z-rna; zbp1; z型核酸; 坏死性凋亡; 炎症; 来源：本站原创 2020-03-26 21:38

撰稿 | 中国医学科学院苏州系统医学研究所马烽研究员&陈盛川博士 审校 | 马烽研究员 01 研究背景介绍：Z型核酸(Z-NA)包括Z-DNA和Z-RNA，是左旋型态的双股螺旋核酸。ZBP1是一种Z-NA识别蛋白，包含两个能结合Z-D…

2020年3月24日 · 左手螺旋核酸在结构上于右手螺旋核酸有很大不同。1970年，Robert D. Wells首次报道了左手螺旋的双链DNA（Z-DNA）【1】。随后，Alexander Rich作为最早研究左手螺旋核酸的研究者之一，他发现由胞嘧啶和鸟嘌呤形成的重复序列（CG-repeat DNA）能够在超高盐浓度下由右手螺旋转变为左手螺旋并解析出左手螺旋 ...

2019年1月7日 · Left-handed Z-DNA/Z-RNA is bound with high affinity by the Zα domain protein family that includes ADAR (a double-stranded RNA editing enzyme), ZBP1 and viral orthologs regulating innate immunity. Loss-of-function mutations in ADAR p150 allow persistent activation of the interferon system by Alu dsRN …

Z-RNA is a higher-energy, left-handed conformation of RNA, whose function has remained elusive. A growing body of work alludes to regulatory roles for Z-RNA in the immune response. Here, we review how Z-RNA features present in cellular RNAs-especially containing retroelements-could be recognized by …