我国学者发现一种潜在对抗肥胖和炎症的抑制剂——ZFP423
Jan 22, 2021 · 根据上述实验结论，研究团队设计出一种名为ZFP423的分子。 尽管脂肪含量没有任何改变，但是ZFP423分子可以抑制动物全身性炎症，并且能影响白色脂肪细胞、脂肪祖细 …
Science 解读-Zfp423 基因敲除可增加脂肪细胞产热_生物器材网
Jan 5, 2023 · 为了确定提高脂肪细胞的产热是否可以缓解体重增加，并抵抗错误节律进食导致的肥胖，研究者们使用了脂肪细胞锌指蛋白 423 (Zinc finger protein 423，Zfp423) 基因敲除小鼠 …
Transcriptional control of preadipocyte determination by Zfp423
Mar 3, 2010 · Zfp423 regulates Pparg expression, in part, through amplification of the BMP signalling pathway, an effect dependent on the SMAD-binding capacity of Zfp423. This study …
Promotion effect of TGF-β-Zfp423-ApoD pathway on lip sensory …
Jun 8, 2023 · TGF-β inhibited the expression of STAT3 and the transcription of ApoD in Schwann cells through Zfp423. Overall, after sacrificing the inferior alveolar nerve, the collateral …
Zfp423 Maintains White Adipocyte Identity through Suppression …
Jun 14, 2016 · Here, we report that the transcriptional regulator Zfp423 is critical for maintaining white adipocyte identity through suppression of the thermogenic gene program. Zfp423 …
Thyroid hormones regulate Zfp423 expression in regionally …
Feb 28, 2023 · Roth et al. show that thyroid hormones directly regulate the gene transcription of Zfp423, an essential determinant of preadipocyte commitment in white fat. This indicates a link …
Zfp423 zinc finger protein 423 [ (house mouse)] - National Center …
Feb 10, 2025 · ZFP423 controls EBF2 coactivator recruitment and PPARgamma occupancy to determine the thermogenic plasticity of adipocytes. ZFP423 regulates early patterning and …
Zfp423 Expression Identifies Committed Preadipocytes and …
Feb 8, 2012 · The identification of Zfp423 as a preadipocyte determination factor afforded an excellent opportunity to isolate committed and functionally relevant adipose progenitors. Here, …
Zfp423/ZNF423 regulates cell cycle progression, the mode of cell ...
ZNF423 participates in the DNA-damage response (DDR), raising questions regarding its role as a regulator of neural progenitor cell cycle progression in cerebellar development. To …
文献解读------Zfp423 Regulates Sonic Hedgehog Signaling via …
Mar 12, 2023 · ZFP423是一个编码30个 锌指蛋白 的转录因子，参与多个经典信号通路。 ZFP423突变引起纤毛疾病相关的表型，包括小鼠 小脑蚓 部发育不全，在人上表现为Joubert …