2024年5月23日 · Zonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover ZO-1 interactions...

ZO-1 was the first tight junction protein to be discovered. 22 It is a cytosolic peripheral membrane protein with multiple domains specialized for protein interactions. Among these are three PDZ (PSD95/Dlg/ZO-1) domains, a Src homology-3 (SH3) domain, …

In vitro and in vivo studies have linked downregulation of the scaffolding protein ZO-1, encoded by the TJP1 gene, to increased tight junction permeability. This has not, however, been tested in vivo. Here, we assessed the contributions of ZO-1 to …

2021年9月25日 · Zonula occludens-1 (ZO-1) was the first identified tight junction (TJ) protein and is a member of a large family of membrane-associated scaffolding and signaling molecules known as membrane-associated guanylate kinase homologues. 1 ZO-1 is conventionally regarded as forming a multidomain scaffold that coordinates the assembly of transmembrane ...

ZO-1 makes critical, tight junction-independent contributions to Wnt signaling and mitotic spindle orientation. As a result, ZO-1 is essential for mucosal repair. We speculate that ZO-1 down-regulation may be one cause of ineffective mucosal healing in patients with IBD.

Here, we demonstrate that the tight junction protein ZO-1 regulates tension acting on VE-cadherin–based adherens junctions, cell migration, and barrier formation of primary endothelial cells, as well as angiogenesis in vitro and in vivo.

2025年3月30日 · TJP1 (Tight Junction Protein 1) is a Protein Coding gene. Diseases associated with TJP1 include Arrhythmogenic Right Ventricular Cardiomyopathy and Brain Edema. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Gene expression (Transcription).

tight junction protein ZO-1, zona occludens 1, zonula occludens 1 protein. IL-8 promotes lens capsular residual cells migration by down-regulates expression of E-cadherin and ZO-1 via the CXCR1/2-NF-kappaB-RhoA signal pathway. TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta.

2017年1月1日 · The zonula occludens (ZO-1) protein-1 is a membrane-associated component of both tight junctions (TJ) and adherens junctions (AJ) found at the site of cell–cell contact.

Zonula occludens-1 (ZO-1) is a scaffolding protein of tight junctions, which seal adjacent epithelial cells, that is also expressed in adherens junctions. The distribution pattern of ZO-1 differs among stratified squamous epithelia, including that between skin and oral buccal mucosa.