ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells, and a subset of B cells). [5] It is most prominently known to be recruited upon antigen binding to the T cell receptor (TCR), and it plays a critical role in T cell signaling.

ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease.

2025年3月30日 · ZAP70 (Zeta Chain Of T Cell Receptor Associated Protein Kinase 70) is a Protein Coding gene. Diseases associated with ZAP70 include Immunodeficiency 48 and Autoimmune Disease, Multisystem, Infantile-Onset, 2. Among its related pathways are Immune response NFAT in immune response and TCR Signaling (Qiagen).

The tyrosine ZAP-70 (zeta-associated protein of 70 kDa) kinase plays a critical role in activating many downstream signal transduction pathways in T cells following T-cell receptor (TCR) engagement. The importance of ZAP-70 is evidenced by the severe combined immunodeficiency that occurs in ZAP-70-d …

1992年11月13日 · We have recently identified a 70 kd tyrosine phosphoprotein (ZAP-70) that associates with ζ and undergoes tyrosine phosphorylation following TCR stimulation. Here we report the isolation of a cDNA clone encoding ZAP-70. ZAP-70 represents a novel PTK and is expressed in T and natural killer cells.

zap70，即ζ链相关激酶70，别名srk、std、tzk等。它来源于人类基因表达，编码一种属于酪氨酸激酶家族的蛋白质。zap70在t细胞和nk细胞中表达，主要参与t细胞受体（tcr）的信号转导途径，通过其酪氨酸激酶活性激活t细胞和nk细胞的免疫活性。

2006年2月16日 · ZAP-70 expression has been reported in normal mouse B lineage cells and in human malignant B lymphocytes, mainly in chronic lymphocytic leukemia (CLL) where it correlates with clinical outcome.

ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia. A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands. TREM-2 promotes Th1 responses by interacting with the CD3zeta-ZAP70 complex following Mycobacterium tuberculosis infection.

2022年8月31日 · In an elegant study using in-depth time-resolved analyses of the total TCR-stimulated phosphoproteome and protein–protein interactions in CD8 + T cells, the authors identify full activation of the...

2018年4月26日 · In this article, we describe recent structure-based insights into the regulation and substrate specificity of ZAP-70, and then we review novel methods for determining the role of ZAP-70 catalytic activity-dependent and -independent signals in developing and mature T cells.