2025年3月30日 · YTHDC1 (YTH N6-Methyladenosine RNA Binding Protein C1) is a Protein Coding gene. Diseases associated with YTHDC1 include Periosteal Chondrosarcoma and Hepatoblastoma. Among its related pathways is Chromatin Regulation / Acetylation.

2022年5月2日 · YTHDC1 is a nuclear m 6 A reader and exerts important effects in modulating many biological processes and diseases, especially cancers. YTHDC1 can recognize different targets and mediates...

2025年3月20日 · The mechanism for preventing RDIBs is orchestrated by YTHDC1 along with the THO complex, which functions to suppress phenotypes caused by alkylation-induced RNA damage, including R-loop production, DNA double-stranded break formation, and alkylation hypersensitivity.

2017年10月6日 · YTHDC1 interacts with the splicing factor and nuclear export adaptor protein SRSF3, and facilitates RNA binding to both SRSF3 and NXF1. This role for YTHDC1 expands the potential utility of chemical modification of mRNA, and supports an emerging paradigm of m 6 A as a distinct biochemical entity for selective processing and metabolism of ...

2025年2月8日 · METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1. YTHDC1 inhibits osteoclast differentiation to alleviate osteoporosis by enhancing PTPN6 messenger RNA stability in an m6A-hUR-dependent manner.

2021年12月30日 · YTHDC1 has distinct functions as a nuclear N 6 -methyladenosine (m 6 A) reader in regulating RNA metabolism. Here we show that YTHDC1 is overexpressed in acute myeloid leukemia (AML) and that it is required for the proliferation and survival of …

YTHDC1 is associated with the pre-mRNA 3’ end processing factors CPSF6, SRSF3, and SRSF7. Thus, YTHDC1 plays a critical role in processing of pre-mRNA transcripts in the oocyte nucleus and may have similar non-redundant roles throughout fetal development.

2021年3月3日 · Here we show that the m 6 A reader YT521-B homology-domain-containing protein 1 (YTHDC1) is required for the maintenance of mouse embryonic stem (ES) cells in an m 6 A-dependent manner, and that...

2021年12月14日 · Here, we summarise current progress in the study of YTHDC1 function in cells, highlighting its multiple modes of action in regulating gene expression, and propose the formation of YTHDC1 nuclear condensates as a general mechanism that underlies its diverse functions in …

Specifically, we show that YTHDC1 regulates alkylation damage responses with the THO complex (THOC). In addition to its established binding to N6-methyladenosine (m 6 A), YTHDC1 binds to chemically induced N1-methyladenosine (m 1 A).