2018年2月2日 · Yes-associated protein (YAP1) appears to control cell proliferation and differentiation. In this study, we sought to identify the roles of YAP in intestinal epithelial cell (IEC) self-renewal, regeneration and tumorigenesis.

2018年2月2日 · Impaired epithelial regeneration is a crucial pathophysiological feature of ulcerative colitis (UC). Yes-associated protein (YAP1) appears to control cell proliferation and differentiation....

1 天前 · YAP1 激活 SLC2A1 转录，通过 Wnt/β-catenin 信号通路促进结直肠癌进展：潜在治疗新靶点 《Cell Division》：YAP1 activates SLC2A1 transcription and augments the malignant behavior of colorectal cancer cells by activating the Wnt/β-catenin signaling pathway 【字体： 大 中 小 】 时间：2025年04月05日 来源：Cell Division 2.8

2015年8月13日 · The transcriptional regulators YAP and TAZ are found to be the key downstream effectors of alternative Wnt signaling to mediate the effects of Wnt ligands on cell migration and osteogenic differentiation, as well as negative regulation of canonical Wnt/β-catenin signaling.

1 天前 · The YAP1- SLC2A1 axis activated the Wnt/β-catenin by reducing GSK3β activity. SLC2A1 is critical in CRC progression, with YAP1 serving as a key regulator of its expression and function. The YAP1-SLC2A1-Wnt axis represents a potential therapeutic target for CRC, providing insights into metabolic adaptations that support tumor growth and ...

2014年7月3日 · In Wnt-OFF cells, YAP/TAZ are essential for β-TrCP recruitment to the complex and β-catenin inactivation. In Wnt-ON cells, release of YAP/TAZ from the complex is instrumental for Wnt/β-catenin signaling. In line, the β-catenin-dependent maintenance of ES cells in an undifferentiated state is sustained by loss of YAP/TAZ.

2025年1月10日 · YAP1 is a potential novel prognostic marker in ACC patients. Its deregulation contributes to adrenocortical tumorigenesis partially through crosstalk between Hippo/YAP1 and Wnt/beta-catenin pathways. YAP1 inhibition is a new antitumor target.

本研究旨在探索YAP基因及Wnt/β-catenin通路在调控醛固酮的分泌与合成以及醛固酮瘤的发生中的作用；通过进一步建立肾上腺皮质条件性转基因小鼠模型，研究YAP1通过Wnt/β-catenin通路对于醛固酮瘤的增殖、凋亡以及分泌功能的影响，并通过小分子抑制剂干预这一 ...

2016年12月12日 · YAP1 is a potential target of the Wnt/beta-catenin pathway, which plays an important role in adrenocortical tumors (ACT). The role of YAP1 in adrenocortical tumorigenesis has not been assessed. Aims: To evaluate YAP1 expression in normal adrenals and pediatric ACT and its association with disease outcome.

1 天前 · SLC2A1 is critical in CRC progression, with YAP1 serving as a key regulator of its expression and function. The YAP1-SLC2A1-Wnt axis represents a potential therapeutic target for CRC, providing insights into metabolic adaptations that support tumor growth and metastasis.