Xeroderma pigmentosum, complementation group C, also known as XPC, is a protein which in humans is encoded by the XPC gene. XPC is involved in the recognition of bulky DNA adducts in nucleotide excision repair. [4] It is located on chromosome 3. [5]

2025年3月30日 · XPC (XPC Complex Subunit, DNA Damage Recognition And Repair Factor) is a Protein Coding gene. Diseases associated with XPC include Xeroderma Pigmentosum, Complementation Group C and Xeroderma Pigmentosum Group C. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair …

互补组 C 型色素性皮肤病 又称 XPC，是一种人体中由 XPC 基因 编码的 蛋白质。 XPC 参与 核苷酸切除修复 过程中对大块 DNA 加合物的识别。 [5] 它位于3号染色体上 [6]。 该基因编码 核苷酸切除修复 （NER）途径的一个组成部分。 NER通路涉及多种成分，包括 着色性干皮病 （XP）AG和V、 科凯恩综合征 （CS）A和B、毛发硫营养不良（TTD）A组等。 该成分XPC在全球基因组 NER 的早期步骤，特别是损伤识别、开放复合物形成和修复蛋白复合物形成。 [5] XPC-RAD23B …

核苷酸切除修复 （nucleotide excision repair, NER）是一种修复由紫外线和 化学致癌物 引起的各种DNA损伤的重要机制。 许多被 诊断 为着色性干皮病（xeroderma pigmentosum, XP）的患者在编码参与NER机制的蛋白的基因之一中存在突变。 众所周知，这些患者对紫外线引起的皮肤癌的高易感性是由于NER功能的缺乏。 这也告诉我们，NER是对癌症的一种防御。 NER的第一步涉及 XPC蛋白，它是多种XP致病性基因产物之一，它作为一种“传感蛋白”起作用，用于确定DNA结 …

2024年11月14日 · The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA.

2018年7月4日 · Here we show that in the absence of damage, XPC co-localizes with RNA polymerase II (Pol II) and active post-translational histone modifications marks on a subset of class II promoters in human...

One of the most versatile and important defense mechanisms against the accumulation of DNA damage is Nucleotide Excision Repair (NER), in which the Xeroderma pigmentosum group C (XPC) protein plays a prominent role. NER can be divided into Global Genome repair (GG-NER) and Transcription Coupled repair (TC-NER).

The XPC gene provides instructions for making a protein that is involved in repairing damaged DNA. DNA can be damaged by ultraviolet (UV) rays from sunlight and by toxic chemicals, radiation, and unstable molecules called free radicals.

The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a …

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc.