XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.

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2011年1月30日 · We report that triptolide covalently binds to human XPB (also known as ERCC3), a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase …

2015年3月1日 · XPB is an essential core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair: 1) to facilitate the …

核苷酸切除修复 （nucleotide excision repair, NER）是一种修复由紫外线和 化学致癌物 引起的各种DNA损伤的重要机制。 许多被 诊断 为着色性干皮病（xeroderma pigmentosum, XP）的患 …

Helicases are molecular motors known to unwind double-stranded DNA. In a recent issue of Molecular Cell, Fan et al. (2006) revealed the core structure of XPB helicase, a component of …

Here, we determined crystal structures of an Archaeoglobus fulgidus XPB homolog (AfXPB) that characterize two RecA-like XPB helicase domains and discover a DNA damage recognition …

Xeroderma pigmentosum group B and D genes (XPB and XPD respectively) are components of the transcription factor IIH (TFIIH), a nine-subunit complex involved in transcription initiation by …

XPB is a superfamily 2 (SF2) DNA helicase conserved from archaea to human (1,7–10). In transcription, XPB binds dsDNA downstream from the promoter opening location and has …

XPB is an essential core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair: 1) to facilitate the melting of the promoter …