
全新细胞死亡类型——双硫死亡(Disulfidptosis) - 知乎
2023年3月3日 · 溶质载体家族成员 SLC7A11(Solute Carrier Family 7 Member 11,又名 xCT)是溶质转运第 7 家族的第 11 个成员,属于 胱氨酸/谷氨酸逆向转运蛋白 ,主要参与氨 …
xCT: A Critical Molecule That Links Cancer Metabolism to Redox ...
In this review, Liu and colleagues discussed the critical role of xCT cystine/glutamate transporter in regard to redox signaling and cancer metabolism, the molecular mechanisms regulating …
『珍藏版』综述 | SLC7A11/xCT在癌症中的作用——铁死亡,营养 …
激活转录因子4( atf4 )和/或核因子红系相关因子2( nrf2 )是调控压力诱导的slc7a11表达的两个主要转录因子。 此外, p53 可抑制SLC7A11的转录,从而调节铁死亡,在肿瘤抑制中起关键 …
xCT与肿瘤和肿瘤干细胞关系的研究进展 - 仁和软件
system xc-由轻链xCT和重链4F2hc这2个亚基构成,亚基间通过细胞外的共价二硫键连接,system xc-转运功能的实现需要重链和轻链亚基的共同参与 ,其结构及功能见 图 1 。
SLC7A11表达水平决定肿瘤细胞对氧化应激的不同反应 - 知乎
溶质载体家族成员 SLC7A11 (Solute Carrier Family 7 Member 11,又名xCT)是溶质转运第7家族的第11个成员,其编码的SLC7A11蛋白是 胱氨酸/谷氨酸反向转运体 (System Xc-)的关 …
Expression of xCT and activity of system xc− are regulated by …
2015年8月1日 · We report that treating MCF-7 cells with H 2 O 2 leads to nuclear translocation of NRF2, elevated xCT expression, and increased transporter activity. Overexpression of NRF2 …
xCT:一种将癌症代谢与氧化还原信号联系起来的关键分子 …
System x c -胱氨酸/谷氨酸逆向转运蛋白,由轻链亚基(xCT,SLC7A11)和重链亚基(CD98hc,SLC3A2)组成,主要负责胱氨酸的细胞摄取以换取细胞内谷氨酸。 近年来,已 …
In recent years, the xCT molecule has been found to play an important role in tumor growth, progression, metastasis, and multidrug resistance in various types of cancer. Interestingly, …
SLC7A11 expression level dictates differential responses to …
2023年6月21日 · Here we report a surprising finding that, whereas moderate overexpression of SLC7A11 is beneficial for cancer cells treated with H 2 O 2, a common oxidative stress …
Cystine-glutamate antiporter xCT as a therapeutic target for …
Cystine/glutamic acid reverse transporter (System X c-), a member of the amino acid transporter family, consists of two subunits, light chain xCT and heavy chain 4F2hc. xCT is the …
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