SLC7A11：SLC家族氨基酸转运蛋白，抗铁死亡！肿瘤耐药新方 …
来自Pharmsnap的数据显示，已有1款靶向SLC7A11抗体在研临床药物（Anti-xCT antibody-drug conjugate (Agilvax)）处于临床前，用于肿瘤治疗。 目前，SLC7A11已被广泛赋予各种癌症类 …
『珍藏版』综述 | SLC7A11/xCT在癌症中的作用——铁死亡，营养 …
胞内半胱氨酸可通过从头生物合成（通过转硫途径）或通过蛋白质降解回收，大多数癌细胞主要依靠胱氨酸转运蛋白系统 Xc-（由催化亚基SLC7A11和伴侣亚基SLC3A2组成）从细胞外环境获 …
Cystine/glutamate transporter - Wikipedia
The SLC7A11 gene encodes a sodium-independent cystine-glutamate antiporter that is chloride dependent, also known as xCT. Along with a heavy chain subunit from SLC3A2, the SLC7A11 …
xCT: A Critical Molecule That Links Cancer Metabolism to Redox ...
In this review, Liu and colleagues discussed the critical role of xCT cystine/glutamate transporter in regard to redox signaling and cancer metabolism, the molecular mechanisms regulating …
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient ...
The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple …
「国自然大热」铁死亡专题（二）铁死亡与肿瘤耐药 - 知乎
xct 和 谷胱甘肽过氧化物酶 (gpx4)是铁死亡过程的关键调控分子。xct用胞外胱氨酸交换胞内谷氨酸，作为细胞内主要抗氧化剂谷胱甘肽(gsh)的来源，xct可抑制脂质过氧化作用，从而抑制铁死 …
xCT与肿瘤和肿瘤干细胞关系的研究进展 - 仁和软件
在肿瘤干细胞（CSC）中，xCT促进CSC表面标记蛋白的表达，与维持CSC的干性特征密切相关，是肿瘤治疗的潜在靶点之一，并且有望应用于肿瘤的临床筛查。 现通过回顾近年来xCT的相 …
Cystine-glutamate antiporter xCT as a therapeutic target for …
Cystine/glutamic acid reverse transporter (System X c-), a member of the amino acid transporter family, consists of two subunits, light chain xCT and heavy chain 4F2hc. xCT is the …
SLC7A11/xCT in cancer: biological functions and therapeutic ...
2020年10月1日 · As the functional component of system Xc-, which imports extracellular cystine with intracellular glutamate release at a ratio of 1:1, SLC7A11 has diverse functional roles in …
SLC7A11/xCT in cancer: biological functions and therapeutic ...
System Xc- is a Na +-independent, chloride-dependent anionic L-cystine/L-glutamate antiporter on the cell surface and mediates the uptake of extracellular cystine in exchange for the …