2023年3月17日 · In this study, by using XBP1 conditional knockout mice, we found that XBP1s is critical for IL-15-mediated NK cell survival but not proliferation in vitro and in vivo. Mechanistically, XBP1s regulates homeostatic NK cell survival by targeting PIM-2, a critical anti-apoptotic gene, which in turn stabilizes XBP1s protein by phosphorylating it at ...

2023年3月10日 · In the current study, although we confirm that XBP1 does not affect NK cell homeostasis and maturation at steady state, our findings reveal that the endogenous XBP1 is important for NK cell survival and effector functions under conditions of excessive IL-15, tumor challenge, and inflammation.

2018年12月10日 · Interleukin 15 (IL-15) is one of the most important cytokines that regulate the biology of natural killer (NK) cells 1. Here we identified a signaling pathway—involving the...

XBP1s positively regulated the cytolytic activity of NK cells against leukemia cells and was also required for IL-15-mediated NK cell survival through an anti-apoptotic mechanism. Thus, the newly identified IL-15-AKT-XBP1s signaling pathway contributes to enhanced effector functions and survival of human NK cells.

余建华课题组前期研究首次发现XBP1s是 人NK细胞 中IL-15/AKT信号通路下游非常重要的转录因子，IL-15通过XBP1s调控人NK细胞的存活和效应功能【2】。此外，哈佛大学Glimcher教授课题组报道XBP1s参与调控了 小鼠NK细胞 的抗病毒效应【9】。然而，XBP1s通过何种分子机制 ...

2019年5月13日 · Natural killer (NK) cells are critical mediators of host immunity to pathogens. Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its...

2024年8月10日 · XBP1 in plasma cells can be activated through NK cells with high inflammation and monocytes with enhanced bacterial defense. At the transcriptional level, leukocyte migration is induced by unfolded protein response (UPR)-stimulated monocytes.

Interleukin 15 (IL-15) is one of the most important cytokines that regulate the biology of natural killer (NK) cells1. Here we identified a signaling pathway—involving the...

In pancreatic α cells, XBP1 deficiency causes glucose intolerance and insulin resistance due to dysregulated glucagon secretion. Knocking down XBP1 increases IRE1α and Jun NH2-terminal kinase (JNK) phosphorylation, resulting in impaired insulin signaling, and subsequently, the inability of insulin to suppress glucagon secretion .

2020年7月1日 · The IRE1α-XBP1-cMyc axis is engaged in NK cell-mediated antitumour immunity. Tumour-associated macrophages advance malignant progression through a distinctive component, and macrophage-derived cathepsins can …