The molecular basis of regulation of bacterial capsule assembly by Wzc …
2021年7月16日 · Gram-negative species couple polymerization with translocation across the periplasm and outer membrane and the master regulator of the system is the tyrosine …
Rational targeting of Wzb phosphatase and Wzc kinase …
2020年6月1日 · Wzc exhibits auto-phosphorylation protein tyrosine kinase activity, while Wzb is a protein tyrosine phosphatase. Wzb mediates dephosphorylation of Wzc. Dephosphorylated …
Wza the translocon for E. coli capsular polysaccharides ... - Nature
2006年11月1日 · Wzy-dependent polymerization requires the activity of the tetrameric Wzc protein 10. Wzb is a protein tyrosine phosphatase enzyme responsible for dephosphorylating …
Wza gene knockout decreases Acinetobacter baumannii virulence …
Expression levels of wzb, wzc and wzi were decreased in wza knockout strains. The antioxidant capacity of Wza knockout bacteria was only slightly decreased. Complementation of the wza …
The role of the tyrosine kinase Wzc (Sll0923) and the phosphatase Wzb …
2019年1月23日 · The results obtained demonstrate that Wzc (Sll0923) and Wzb (Sll0328) are involved in the production of EPS, influencing both the amount and the composition of …
Structural basis for the recognition of the bacterial tyrosine kinase ...
The structure of the Wzb–Wzc CDΔC complex determined here not only reveals key structural features that enable molecular recognition between these two species but also provides a …
Functional Analysis of Conserved Gene Products Involved in …
In this biosynthesis pathway, Wza, Wzb, and Wzc homologues are required for surface expression of wild-type CPS or EPS. Multimeric complexes of Wza in the outer membrane are …
Rational targeting of Wzb phosphatase and Wzc kinase …
EPS synthesis and its export is regulated by the bacterial Wza-Wzb-Wzc system. Wzc exhibits auto-phosphorylation protein tyrosine kinase activity, while Wzb is a protein tyrosine …
Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, …
Two proteins of Escherichia coli, termed Wzc and Wzb, were analyzed for their capacity to participate in the reversible phosphorylation of proteins on tyrosine. First, Wzc was …
Capsular Types of Klebsiella pneumoniae Revisited by wzc
2013年12月9日 · Notably, the typical wzb-wzc locus of the cps region was replaced by transposase-like genes in these two capsular types. The wzb and wzc genes may have been …