Wobble base pairs are fundamental in RNA secondary structure and are critical for the proper translation of the genetic code. In the genetic code, there are 4 3 = 64 possible codons (three- nucleotide sequences). For translation, each of these codons requires a tRNA molecule with an anticodon with which it can stably complement.

变偶假说（ wobble hypothesis）又名摆动假说Crick为解释 反密码子 中某些稀有成分的配对以及许多 氨基酸 有两个以上 密码子 的问题而提出的假说。 一种氨基酸对应两种以上的 密码子 时经常是一种 tRNA 要识别几种密码子，为了说明这种tRNA对密码子识别的多样性，克里克（F．H．C．Crick，1966）提出了这种假说。 当密码子和反密码子配对的时候，密码子的第三个碱基（3′末端）与反密码子 5′端 碱基的配对是松弛的可有摆动（Wo-bble），可以认为除华森- …

2023年8月17日 · The relaxed base-pairing requirement, or “wobble,” allows the anticodon of a single form of tRNA to pair with more than one triplet in mRNA. The rules: first base U can recognize A or G, first base G can recognize U or C, and first base I can recognize U, C or A.

2021年4月15日 · Nature Communications - Wobble uridine (U34) tRNA modifications are important for the decoding of AA-ending codons. Here the authors show that while the U34-codon content of mRNAs are...

2016年1月21日 · We show that mnm5s2U forms an unusual pair with guanosine at the wobble position that expands general knowledge on the degeneracy of the genetic code and specifies a powerful role of tRNA ...

2007年2月9日 · Post-transcriptional modifications at tRNA's wobble position 34, especially modifications of uridine 34, enable wobble to occur. The Modified Wobble Hypothesis proposed in 1991 that specific modifications of a tRNA wobble nucleoside shape the anticodon architecture in such a manner that interactions were restricted to the complementary base ...

By direct sequence of several tRNA molecules, the wobble hypothesis is confirmed which explains the pattern of redundancy in genetic code in some anticodons (e.g. the anticodons containing U, I and G in the first position in 5’→ 3′ direction)

2024年10月15日 · In fact, in a study of E. coli's tRNA for alanine there is a wobble base pair that determines whether the tRNA will be aminoacylated. When a tRNA reaches an aminoacyl tRNA synthetase, the job of the synthetase is to join the t-shaped RNA with its amino acid.

摆动假说（Wobble Hypothesis）是由美国生物化学家弗朗西斯·克里克（Francis Crick）于1966年提出的，用于解释tRNA分子识别多种密码子的机制。 这一假说指出，tRNA反密码子的第一个核苷酸（从5'端数起的第一个位置，即反密码子的第34位核苷酸）可以通过不严格的碱基配对与mRNA密码子的第三个核苷酸（即3'端的第一个位置）结合。 这种不严格的配对允许一个tRNA识别多个不同但相似的密码子，从而增加了翻译过程的灵活性。 ### 核心概念. 1. **密码子和反密 …

2024年6月24日 · The wobble hypothesis explains how fewer tRNA molecules can recognize multiple codons coding for the same amino acid. This reduces the number of tRNA species required for protein synthesis, streamlining the translation process and making it more efficient.