2023年6月4日 · Wnt信号通路 是胚胎及器官发育的重要信号通路之一，参与调控机体内多种细胞的增殖、分化、极化、迁移及凋亡等过程。 Wnt信号通路根据是否依赖于 β-catenin 的转录活化，可分为经典通路（即 Wnt／β-catenin信号通路）和非经典通路（包括Wnt／PCP通路和 Wnt-Ca2+通路）。 2017年5月，美国斯坦福大学医学院的 Roel Nusse 教授和荷兰乌得勒支大学医学中心 Hans Clevers 教授在《Cell》期刊（IF=66.89）上发表题为“ Wnt/b-Catenin Signaling, Disease, and …

日前，山东大学贾继辉教授研究团队在《Cell Death & Differentiation》（2021 IF:15.828）在线发表了题为“Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer”的研究结果。 该研究探究了在幽门螺杆菌感染的过程中Wnt/β-catenin信号通路与铁死亡之间的关系，阐明幽门螺杆菌激活Wnt/β-catenin信号通路调控铁死亡在胃部恶性转化中的作用机制，为增强肿瘤的化疗敏感性提供新策略。 研究方法与结果. 抑制Wnt/β-catenin信号通路可特异 …

2021年5月5日 · Hua等 发现tribbles假性激酶3 (tribbles homolog 3, TRIB3) 通过与β-catenin及TCF4形成异源三聚体, 活化了Wnt信号通路, 进而维持了结直肠癌干细胞特性, 促进结直肠癌的复发与耐药。为了筛选有效的多肽抑制剂, 研究者首先基于TRIB3的分子结构设计了与TRIB3具有良好亲 …

2022年9月15日 · In the nucleus, T cell factor (TCF) and lymphoid enhancer-binding factor (LEF) proteins interact with transcriptional co-repressors from the Groucho/TLE family, blocking the expression of Wnt target genes.

2022年5月9日 · Here, we show that the activation of the Wnt/beta-catenin signaling attenuates cellular lipid ROS production and subsequently inhibits ferroptosis in GC cells. The beta-catenin/TCF4...

T-cell factor 4 (TCF4), together with β-catenin coactivator, functions as the major transcriptional mediator of the canonical wingless/integrated (Wnt) signaling pathway in the intestinal epithelium. The pathway activity is essential for both ...

2018年9月1日 · Here, we present the results obtained using a newly generated conditional Tcf4 allele that allows inactivation of all potential Tcf4 isoforms in the mouse tissue or small intestinal and colon organoids. We also employed the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system to disrupt the TCF4 gene in human cells.

TCF4与Axin(轴蛋白)均是Wnt信号通路中的重要效应因子，在调节干细胞自我更新、细胞增殖、分化及凋亡，参与胚胎发育、组织稳态及细胞癌变等方面扮演重要角色，被认为在多种组织的发展和肿瘤发生中起重要作用。

2017年1月4日 · The expression of VGLL4 is significantly downregulated in clinical colorectal carcinoma (CRC) specimens, positively associated with patient survival rate, and inversely correlated with the expression of Wnt target genes in CRCs. Knockdown of VGLL4 enhances proliferation and tumour formation of CRC cells.

1 天前 · The Wnt signaling pathway is critically involved in orchestrating cellular functions such as proliferation, migration, survival, and cell fate determination during development. Given its pivotal ...