TCF/LEFs and Wnt signaling in the nucleus - PubMed
2012年11月1日 · T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …
经典信号通路总结——Wnt信号通路 - 知乎 - 知乎专栏
简单来说，当细胞没有接受Wnt信号刺激时 (Wnt Off)，细胞质内的Axin、APC和GSK3β形成毁灭复合体（destruction complex），与β-Catenin结合并使其被磷酸化后，最终通过泛素化修饰而 …
来看！为你翻译了这篇Cell综述，不再遗憾错过Wnt信号通路 - 知乎
2023年6月4日 · Wnt信号通路是胚胎及器官发育的重要信号通路之一，参与调控机体内多种细胞的增殖、分化、极化、迁移及凋亡等过程。 Wnt信号通路根据是否依赖于 β-catenin的转录活 …
Wnt信号通路是在后生动物细胞内高度保守的关键信号通路, 它参与调控胚胎的早期发育、成体的组织稳态维持、干细胞自我更新、细胞命运决定、细胞分裂以及肿瘤发生发展等多种生物学过 …
Wnt/β-catenin 信号通路_非经典wnt信号通路-CSDN博客
2024年11月28日 · 经典 Wnt 通路，也称为 Wnt/β-catenin 通路，涉及 β-catenin 的核转位和通过 TCF/LEF 转录因子激活靶基因。 经典 Wnt 通路主要控制细胞增殖，而非经典 Wnt 通路调节细 …
Wnt signaling pathways in biology and disease: mechanisms and ...
5 天之前 · Genetic mutations affecting the Wnt pathway play a pivotal role in disease progression, with particular emphasis on Wnt signaling’s involvement in cancer stem cell biology and the …
Wnt signaling in cancer: from biomarkers to targeted therapies …
2025年4月2日 · These biomarkers are involved in key regulatory steps of Wnt signaling and can help assess the tumor's responsiveness to Wnt-targeted therapies. Additionally, alterations in …
Wnt/β-catenin and notch signaling pathways in cardiovascular …
2025年1月1日 · The canonical Wnt signaling pathway prevents the degradation of cytosolic β-catenin and activates β-catenin/TCF transcriptional responses. By inhibiting GSK-3β activity, β …
Induction of zinc conjugated with Doxorubicin for the prevention …
1 天前 · Speculating the investigation of the binding of Doxorubicin and Zn conjugated Doxorubicin to the Tcf-binding sites of β-catenin aims to inhibit the interaction between Tcf and …
Transcription factor NFKB1 mediates TUBB6 to promote the
2025年4月1日 · TCF/LEF1 is a recognized downstream target gene of the Wnt/β-catenin signaling pathway. We found that silencing TUBB6 significantly decreased TCF/LEF1 luciferase activity …