2020年12月1日 · We report that in adipocytes, the canonical Wnt/β-catenin pathway regulates de novo lipogenesis (DNL) and fatty acid monounsaturation. Further, β-catenin mediates effects of Wnt signaling on lipid metabolism in part by transcriptional regulation of Mlxipl and Srebf1.

2024年7月5日 · The finding of Wnt signaling-induced repression of Lsd-1 and Lsd-2 prompted us to hypothesize that active Wnt signaling reduces the presence of LDAPs, including Lsd-1 and Lsd-2, on the surface of lipid droplets in adipocytes; this reduction may increase the access of lipases to TGs stored within lipid droplets, thereby stimulating lipid ...

Results: We report that in adipocytes, the canonical Wnt/β-catenin pathway regulates de novo lipogenesis (DNL) and fatty acid monounsaturation. Further, β-catenin mediates effects of Wnt signaling on lipid metabolism in part by transcriptional regulation of Mlxipl and Srebf1.

近日，英国弗朗西斯·克里克研究所Jean-Paul Vincent教授与牛津大学E. Yvonne Jones教授团队合作在Nature杂志发表了题为Glypicans shield the Wnt lipid moiety to enable signalling at a distance的研究文章，发现磷脂酰肌醇蛋白聚糖Dlp的蛋白核心能通过构象变化形成疏水空间，进而 …

2022年1月3日 · sFRPs, WIF, glypicans, Tiki, and Notum are well-known regulators of Wnt/β-catenin signalling that target Wnt proteins to affect signal transduction. sFRPs have a Netrin-related motif in the C...

2020年7月22日 · Here we provide evidence against these models and show that the Wnt lipid is shielded by the core domain of a subclass of glypicans defined by the Dally-like protein (Dlp). Structural analysis...

2003年4月27日 · Enzymatic removal of the palmitate or site-directed and natural mutations of the modified cysteine result in loss of activity, and indicate that the lipid is important for signalling. The...

2015年4月7日 · We show that Wnt3a stimulates the production of lipid droplets and that this stimulation strictly depends on endocytosed, LDL-derived cholesterol and on functional early and late endosomes. We also show that Wnt signaling itself controls cholesterol endocytosis and flux along the endosomal pathway, which in turn modulates cellular lipid ...

We demonstrate that secreted FZD-related proteins and WNT inhibitory factor 1 are WNT carriers, potently releasing lipidated WNTs and forming active soluble complexes. WNT release occurs by direct handoff from the membrane protein WNTLESS to the carriers.

为了研究经典 Wnt 通路在调节脂肪细胞代谢中的作用，我们生成了脂肪细胞特异性 β-连环蛋白 ( β-cat) 敲除小鼠和培养细胞模型。我们使用 RNA 测序、ChIP 测序和分子方法来评估 Wnt 靶标和脂肪生成基因的表达。