细胞动态可塑性：Wnt/β-catenin 如何 "燎动" 肿瘤 EMT ？
2. EMT 与 Wnt/β-catenin 通路. EMT 受多种信号通路调节，例如 TGF-β 、Wnt/β-catenin、 Hedgehog 和 Notch 信号通路 ，这些途径通过刺激 Snail 、 Twist 和 ZEB1/2 等转录因子来触发 …
经典信号通路总结——Wnt信号通路 - 知乎 - 知乎专栏
简单来说，当细胞没有接受Wnt信号刺激时 (Wnt Off)，细胞质内的Axin、APC和GSK3β形成毁灭复合体（destruction complex），与β-Catenin结合并使其被磷酸化后，最终通过泛素化修饰而 …
Wnt/β-catenin-driven EMT regulation in human cancers - PMC
Among the different regulators of EMT, Wnt/β-catenin axis has been emerged as a versatile modulator. Wnt is in active form in physiological condition due to the function of GSK-3β that …
国自然划重点：红透半边天的EMT机制研究及相关通路 - 知乎
• TGFβ信号-OVOL2双负反馈环在乳腺癌上皮-间质转化（EMT）中的作用机制. 2.Wnt信号通路. Wnt信号通路不仅在胚胎发育中发挥了一定的作用，而且与许多人类肿瘤的发生发展也有密切 …
Wnt/β-catenin通路的激活途径及其相关调控在肿瘤研究的应用
2023年11月10日 · EMT 受多种信号通路调节，例如 TGF-β、Wnt/β-catenin、Hedgehog 和 Notch 信号通路，这些途径通过刺激 Snail、Twist 和 ZEB1/2 等转录因子来触发 EMT。 在所有信号 …
Wnt/β-catenin signalling, epithelial-mesenchymal transition and ...
2024年6月1日 · Persistent Wnt/β-catenin signalling facilitates the epithelial-mesenchymal transition (EMT), which accelerates CRC invasion and metastasis. This review provides a …
Wnt signaling in cancer: from biomarkers to targeted therapies …
4 天之前 · Wnt signaling pathways are essential for various biological functions, including tissue homeostasis maintenance and embryonic development [1, 2].Disruption of these pathways …
Wnt signaling pathways in biology and disease: mechanisms and ...
2 天之前 · The Wnt signaling pathway is critically involved in orchestrating cellular functions such as proliferation, migration, survival, and cell fate determination during development. Given its …
The NcRNA/Wnt axis in lung cancer: oncogenic mechanisms, …
2025年3月14日 · Similarly, the oncogenic miR-103 targets and downregulates the tumor suppressor kruppel like factor 7 (KLF7), activating Wnt/β-catenin signaling to induce EMT . In …
Wnt/β-catenin signalling: function, biological mechanisms, …
2022年1月3日 · Wnt signalling plays an important role in the self-renewal of some tissues in mammals. For example, the Wnt signalling pathway is related to the development and renewal …