Wnt信号通路（主要基因/通路基因分类/信号通路图 - 知乎
2023年10月11日 · AXIN1和AXIN2基因编码Axin蛋白，是Wnt信号通路中另一个重要的负调节因子。 Axin蛋白能够与β-catenin和GSK-3β形成复合物，从而促进β-catenin的降解，抑制Wnt信号 …
An aggregon in conductin/axin2 regulates Wnt/β-catenin ... - Nature
2019年9月18日 · The paralogous scaffold proteins axin and conductin/axin2 are key factors in the negative regulation of the Wnt pathway transcription factor β-catenin, thereby representing …
New insights into the regulation of Axin function in canonical Wnt ...
Axin, a key component of canonical Wnt pathway, plays dual roles in modulating Wnt signaling: on one hand, Axin scaffolds the “β-catenin destruction complex” to promote β-catenin …
Roles of Axin in the Wnt Signalling Pathway - ScienceDirect
1999年11月1日 · Wnt stabilizes cytoplasmic β-catenin, which stimulates the expression of genes including c-myc, c-jun, fra-1, and cyclin D1. Axin, newly recognized as a component of the Wnt …
Axin在Wnt信号转导途径中的作用 - 中国生物化学与分子 ...
Wnt信号转导途径是调控细胞形状、运动、黏附、增殖、分化、癌变及机体发育等过程的主要途径之一.Axin (轴蛋白)是一个体轴发育抑制因子，作为构架蛋白在Wnt信号转导途径中起着关键的 …
USP7 inhibits Wnt/β-catenin signaling through promoting
2019年9月13日 · Our study reveals a critical mechanism that prevents excessive degradation of Axin and identifies USP7 as a target for sensitizing cells to Wnt/β-catenin signaling. The Wnt/β …
Axin在Wnt信号转导途径中的作用 - pku.edu.cn
Wnt信号转导途径是调控细胞形状、运动、黏附、增殖、分化、癌变及机体发育等过程的主要途径之一.Axin (轴蛋白)是一个体轴发育抑制因子,作为构架蛋白在Wnt信号转导途径中起着关键的 …
Wnt regulation: exploring Axin-Disheveled interactions and …
We explore β-cat transfer from the destruction complex to the E3 ligase, and test models suggesting Dishevelled and APC2 compete for association with Axin. We find that Slimb/TrCP …
Roles of Axin in the Wnt signalling pathway - PubMed
Wnt stabilizes cytoplasmic beta-catenin, which stimulates the expression of genes including c-myc, c-jun, fra-1, and cyclin D1. Axin, newly recognized as a component of the Wnt signalling …
Axin在Wnt信号转导途径中的作用 - 百度文库
Axin (轴蛋白)是一个体轴发育抑制因子 (axi8 inhibitor),也是一个肿瘤抑制因子,它谢一系列结合位点,作为檎架蛋自,麓与wnt信号转导途径熬许多重要成员相互结合,在个体发育、细胞增殖及癌变 …