WI-38 is a diploid human cell line composed of fibroblasts derived from lung tissue of a 3-month-gestation female fetus. [1][2] The fetus came from the elective abortion of a Swedish woman in 1963.

2020年11月4日 · Over the ensuing years, frozen vials of the cells were flown to hundreds of laboratories across the world, WI-38 is now one of the oldest and most widely available cell lines on the planet.

We estimate the number of lives saved and morbidity reduction associated with the discovery of the first human cell strain used for the production of licensed human virus vaccines, known as WI-38. The diseases studied include poliomyelitis, measles, mumps, rubella, varicella (chicken pox), herpes zoster, adenovirus, rabies and Hepatitis A.

WI-38 cell line is the first human diploid cell line to be used in human vaccine preparation. WI-38 cells were isolated from the lung tissue of a 3-month-old, female, embryo. WI-38 is used in viruscide testing.

The WI-38 cell line was originally isolated and adapted for viral growth by Hayflick and Moorhead (1961). The accessibility of this ‘normal’ cell line was a monumental step forward in vaccinology as it provided a cell line free from potentially contaminated foreign and oncogenic particles.

A comparison of WI-38, MRC-5, and IMR-90 was performed to evaluate efficiency and speed of viral isolation, clarity of cytophatic effect, and ease of growing the cells. The inocula were clinical specimens rather than tissue culture-adapted isolates.

In this study, we tested whether WI-38 cells, a human embryonic lung fibroblast cell line, could be used to study fibroblast differentiation towards the LIF or MYF phenotype and whether this could be relevant for idiopathic pulmonary fibrosis (IPF).

WI-38 cell line is the first human diploid cell line to be used in human vaccine preparation. WI-38 cells were isolated from the lung tissue of a 3-month-old, female, embryo. WI-38 is used in viruscide testing.

The WI-38 cell line was developed in July 1962 from lung tissue taken from a therapeutically aborted fetus of about 3 months gestational age. Cells released by trypsin digestion of the lung tissue were used for the primary culture.

2012年4月4日 · Biotechnology: Used for the production of live oral adenovirus type 4 and type 7 vaccine used by the US military. Produced first by Wyeth Laboratories from 1971 to 1999 and from 2011 onward by Barr Pharmaceuticals.