制Wee1 激酶活性能够选择性地杀死 p53 功能缺陷 肿瘤细胞，而不影响正常细胞，是一种理想的肿瘤 治疗途径。相关研究表明，Wee1 激酶在乳腺癌、卵 巢癌、肝癌、宫颈癌、肺癌、鳞状细 …
Recent Advances of WEE1 Inhibitors and Statins in Cancers With p53 ...
Tumor cells lacking functional p53 are defective in the G1/S checkpoint and become highly dependent on the G2/M checkpoint to maintain genomic stability and are consequently …
Drugs Targeting p53 Mutations with FDA Approval and in Clinical …
Currently, only adavosertib (AZD1775/MK-1775), a Wee1 inhibitor, is in clinical trials to examine whether it efficiently suppresses the progression of tumors with p53 deletions or mutations …
Recent Advances of WEE1 Inhibitors and Statins in Cancers With p53 …
2021年10月4日 · p53 is among the most frequently mutated tumor suppressor genes given its prevalence in >50% of all human cancers. One critical tumor suppression function of p53 is to …
Wee1 inhibition potentiates Wip1-dependent p53-negative tumor …
2016年4月14日 · We have found that a treatment with a low dose (75 nM) of MK-1775, a recently described specific chemical inhibitor of Wee1, decreases CDDP-induced H2AX …
免疫治疗爆火的当下，合成致死小分子抑制剂也有春天 ——WEE1 …
2021年5月24日 · 而 WEE1 就是合理的与 TP53 相搭配的合成致死靶点。 WEE1 是 DNA 损伤修复（DDR）通路相关的一个重要激酶。WEE1 激酶能磷酸化细胞分裂周期基因 (cell division …
Targeting WEE1 kinase as a p53-independent therapeutic
2023年9月15日 · Targeted inhibition of WEE1 with small-molecule inhibitor adavosertib (AZD1775) has emerged as a therapeutic strategy to sensitize cancer cells to DNA-damaging …
Targeting WEE1 kinase as a p53-independent therapeutic strategy …
2023年9月15日 · Targeted inhibition of WEE1 with small-molecule inhibitor adavosertib (AZD1775) has emerged as a therapeutic strategy to sensitize cancer cells to DNA-damaging …
Targeting WEE1 enhances the antitumor effect of - Cell Press
2024年6月18日 · Fukuda et al. show that combining WEE1 kinase and KRAS-G12C inhibitors nearly eradicates KRAS-mutant NSCLC with TP53 mutations in mouse models. This approach …
WEE1蛋白：细胞周期调控的关键角色及其在肿瘤治疗中的潜力
2024年7月19日 · wee1是一种高度保守的细胞周期调节蛋白，可以抑制细胞进入有丝分裂，促进细胞完成dna复制和修复。wee1与p53存在合成致死效应，被认为是肿瘤药物研发的潜力靶点。 …