The KRAS-regulated kinome identifies WEE1 and ERK coinhibition …
The unexpected paradoxical activation of ERK upon WEE1 inhibition led us to inhibit both WEE1 and ERK concurrently, which caused further potent growth suppression and enhanced …
Defining the KRAS- and ERK-dependent transcriptome in KRAS
Our study established a KRAS-ERK regulated gene signature that detected KRAS-ERK inhibition in KRAS-mutant cancer patients. Coupled with our ERK-dependent total proteome and …
The KRAS-regulated kinome identifies WEE1 and ERK
2021年11月1日 · Concurrent WEE1 and ERK inhibition caused additive or synergistic effects on viability, depending on doses (Fig. 6, B and C). Taken together with anchorage-dependent …
Adavosertib and beyond: Biomarkers, drug combination and …
2024年1月1日 · WEE1 kinase is renowned as an S-G2 checkpoint inhibitor activated by ATR-CHK1 in response to replication stress. WEE1 inhibition enhances replication stress and …
Targeting WEE1 enhances the antitumor effect of - Cell Press
2024年6月18日 · Fukuda et al. show that combining WEE1 kinase and KRAS-G12C inhibitors nearly eradicates KRAS-mutant NSCLC with TP53 mutations in mouse models. This approach …
Targeting AXL and mTOR Pathway Overcomes Primary and …
2017年10月15日 · Conclusions: AXL promotes resistance to WEE1 inhibition via downstream mTOR signaling and resulting activation of a parallel DNA damage repair pathway, CHK1. …
WEE1 confers resistance to KRAS - ScienceDirect
2025年2月28日 · WEE1 overexpression induces sotorasib resistance by promoting MCL-1 upregulation. Dual inhibition of WEE1 and KRAS G12C restores sensitivity in resistant cancer …
WEE1 Ser/Thr protein kinase acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the …
The role and mechanism of WEE1 on the cisplatin resistance …
2015年8月27日 · The results demonstrated that WEE1 negatively regulated the multidrug resistance potential of human hepatic cancer cells by modulating the expression of relevant …
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition …
2021年10月22日 · Concurrent WEE1 and ERK inhibition caused additive or synergistic effects on viability, depending on doses (Fig. 6, B and C). Taken together with anchorage-dependent …