WEE1 kinase limits CDK activities to safeguard DNA replication …
A major regulatory axis is guarded by WEE1 kinase, which directly phosphorylates and inhibits CDK1 and CDK2. The role of WEE1 in the G2/M cell-cycle phase has been thoroughly …
WEE1 kinase protects the stability of stalled DNA replication forks …
2022年1月18日 · Here we show that WEE1 activity guards against nascent DNA2-dependent degradation of stalled replication forks, which is driven by deregulated CDK2 activity. Finally, …
Comprehensive multi-omics analysis reveals WEE1 as a ... - Nature
2024年3月7日 · Based on the phospho-signature, we identify Cyclin-Dependent Kinase 1 (CDK1) to be hyperactivated and responsible for the observed global signaling landscape during HT. …
A novel WEE1 pathway for replication stress responses
2021年2月11日 · It is well known that the evolutionarily conserved protein kinase WEE1 regulates replication stress responses by directly phosphorylating and inhibiting the major cell cycle …
WEE1 kinase limits CDK activities to safeguard DNA replication …
2020年1月1日 · Through inhibitory phosphorylations of the S phase CDK-cyclin complexes, the activity of WEE1 delays S phase onset, limits firing of dormant origins and overall suppresses …
Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects …
We found that acute activation of CDK activity by inhibition of WEE1 kinase stimulates replication through firing of additional origins, leading to nucleotide insufficiency. This reduces replication …
Cell cycle involvement in cancer therapy; WEE1 kinase, a potential ...
2022年1月1日 · WEE1 is a critical target for inhibitors, which can enhance the efficacy of other types of conventional therapy and overcome the resistance to conventional treatment. WEE1, …
WEE1 kinase protects the stability of stalled DNA replication forks …
2022年1月18日 · Here we show that WEE1 activity guards against nascent DNA degradation at stalled forks. Furthermore, we identify WEE1-dependent suppression of cyclin-dependent …
Cyclin-dependent kinase suppression by WEE1 kinase protects
Activation of oncogenes or inhibition of WEE1 kinase deregulates cyclin-dependent kinase (CDK) activity and leads to replication stress; however, the underlying mechanism is not understood. …
A key role of the WEE1-CDK1 axis in mediating TKI-therapy
2022年12月12日 · Here, to identify genotype-driven strategies increasing the TKI therapy efficacy, we developed SignalingProfiler, a strategy supporting the integration of high-sensitive mass …