2023年8月2日 · The loss of SOG1 reduced the resistance of wee1 gcn20 to replication stress, whereas overexpressing SOG1 enhanced the resistance to atr or wee1 to replication stress. …

2021年2月11日 · In this study, through genetic screening, we found that loss of function of an E3 ubiquitin ligase, F-box like 17 (FBL17), suppresses the atr and wee1 mutants to replication …

Inhibitors of WEE1 and ATR kinases are considered promising for cancer treatment, either as monotherapy or in combination with chemo- or radiotherapy. Here, we addressed whether …

2024年7月4日 · ATR, CHK1 and WEE1 are key kinases which, in response to replication stress (RS), signal to S and G2/M cell cycle checkpoints to exploit the nearly ubiquitous dysfunction …

2025年4月1日 · Xu, H. et al. CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Cell Rep. Med. 2, 100394 …

2021年1月16日 · 2021年1月15日，Nucleic Acids Research 发表了以华中农业大学严顺平教授为通讯作者的题为 The ATR-WEE1 kinase module inhibits the MAC complex to regulate …

2021年2月22日 · Through a genetic screen for suppressors of the Arabidopsis atr mutant, we found that loss of function of PRL1, a core subunit of the evolutionarily conserved MAC …

2019年1月15日 · To target mechanisms important for cancer cell adaptation to genotoxic stress and thereby to achieve cancer cell–specific killing, we combined inhibition of the kinases ATR …

The selective WEE1 inhibitor, AZD1775, has shown strong anti-proliferative effects on a variety of tumors. Here, we first demonstrate that inhibition of ATR by selective inhibitor AZD6738 can …

2021年9月21日 · We identified a means to exploit CCNE1 oncogene addiction vulnerabilities with low-dose WEE1 and ATR inhibition, a dosing strategy that should be tolerable and feasible in …