WRN helicase promotes repair of DNA double-strand breaks ... - PubMed
2009年9月1日 · Recent studies in yeast have found that processing of DNA double-strand breaks (DSB) for recombination repair involves Sgs1 helicase. Human cells have five Sgs1 …
Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI ...
2024年4月24日 · Here we report the structural, biochemical, cellular and pharmacological characterization of the clinical-stage WRN helicase inhibitor HRO761, which was identified …
CDK2 phosphorylation of Werner protein (WRN) contributes to ... - PubMed
In a previous report, we showed that WRN protein is recruited to laser-induced DNA double-strand break (DSB) sites during various stages of the cell cycle with similar intensities, …
ATR and ATM differently regulate WRN to prevent DSBs at stalled ...
2010年8月27日 · Here, we report that WRN is directly phosphorylated by ATR at multiple C‐terminal S/TQ residues. Suppression of ATR‐mediated phosphorylation of WRN prevents …
WRN helicase promotes repair of DNA double-strand breaks …
Recent studies in yeast have found that processing of DNA-double strand breaks (DSB) for recombination repair involves Sgs1 helicase. Human cells have five Sgs1 homologues with …
ATR and ATM differently regulate WRN to prevent DSBs at stalled ...
2010年9月15日 · Here, we report that WRN is directly phosphorylated by ATR at multiple C-terminal S/TQ residues. Suppression of ATR-mediated phosphorylation of WRN prevents …
Werner 蛋白 (WRN) 的 CDK2 磷酸化有助于 WRN 的 DNA 双链断 …
在之前的一份报告中，我们发现 WRN 蛋白在细胞周期的不同阶段以相似的强度被招募到激光诱导的 DNA 双链断裂 (DSB) 位点，支持 WRN 参与非同源末端连接 (NHEJ)和同源重组（HR）。 …
Werner syndrome (WRN) DNA helicase and base excision repair …
2019年1月1日 · Werner syndrome protein (WRN) is an ATP-dependent 3´ to 5´ DNA helicase that belongs to the RecQ family. It possesses a RecQ C-terminal (RQC) domain which is important …
Werner Syndrome Protein Is Regulated and Phosphorylated by …
Werner syndrome is a disorder characterized by genomic instability, aging pathologies and defective WRN, a RecQ-like helicase with exonuclease activity. We show that WRN interacts …
CDK2 phosphorylation of Werner protein (WRN ... - Wiley Online Library
2021年10月6日 · Here, we demonstrate that the phosphorylation of WRN by CDK2 on serine residue 426 is critical for WRN to make its DSB repair pathway choice between NHEJ and HR.
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