2018年9月26日 · Worst pattern of invasion (WPOI) (AJCC: Cancer Staging [Accessed 21 September 2018], CAP: Protocol for the Examination of Specimens from Patients with Cancers of the Lip and Oral Cavity [Accessed 29 December 2020]): Validated outcome predictor for oral cavity squamous carcinoma patients in multivariate analysis

Presence of invasive WPOI is associated with advanced T stage, poor differentiation, PNI, greater depth of invasion, and higher chances of nodal metastasis. WPOI is associated with poor DFS, treatment intensification in early stage disease with WPOI type IV & V may improve survival.

The relationship between the worst pattern of invasion (WPOI) and the prognosis of oral squamous cell carcinoma (OSCC) remains controversial. This systematic review and meta-analysis was performed to determine the impact of the WPOI on the prognosis ...

2023年10月18日 · Worst pattern of invasion, abbreviated WPOI, is schema for classifying tumour morphologic patterns with the goal of predicting tumour behaviour.

2024年3月1日 · This study analyses the prognostic significance of worst pattern of invasion (WPOI) in a unique population of pathologically proven node-negative early-stage oral tongue cancer patients to see if the WPOI is a prognostic marker …

In relation to POI, the CAP designates worst pattern of invasion (WPOI) as non-core and optional for reporting. Although 5 patterns of invasion are recognized, distinction of WPOI-5 (defined as dispersion of ≥ 1 mm between tumour satellites), from patterns 1 to 4 is most significant .

最差浸润方式（Worst pattern of invasion，WPOI）是指一个瘤体所具有的最高级别的浸润方式。 本研究团队前期发现，WPOI是早期OSCC患者术后复发的重要影响因素；WPOI 4-5的患者其生存时间明显缩短，且术后出现淋巴结转移的可能性更高。

目的 最坏侵袭模式（wpoi）与口腔鳞状细胞癌（oscc）预后之间的关系仍存在争议。 进行这项系统回顾和荟萃分析是为了确定 WPOI 对 OSCC 预后的影响。 方法 使用纽卡斯尔-渥太华量表对六个数据库的研究进行质量评估，并使用 Stata 软件对数据进行分析。

2023年1月1日 · There is a paucity of literature regarding the association of various clinicopathological parameters with the different patterns of invasion including the worst pattern of invasion (WPOI). The current study aimed to evaluate the association of WPOI in oral squamous cell carcinoma (SCC) with clinicopathological factors.

We propose mandatory reporting of WPOI-4 at the tumor interface and absence of LHR, as significant markers of poor prognosis in early-stage oral cavity squamous carcinoma.