Vps34 PI 3-kinase inactivation enhances insulin sensitivity ... - Nature
2017年11月27日 · Here we show that heterozygous Vps34 kinase-dead mice are healthy and display a robustly enhanced insulin sensitivity and glucose tolerance, phenotypes mimicked by …
【热点】研究自噬不得不说的关键分子 - 知乎
Vps34是哺乳动物中的第III类PI3 Kinase（PIK3C3），磷酸化磷脂酰肌醇（PI）产生磷脂酰肌醇三磷酸（PI3P），这对于自噬泡膜的延伸和ATG蛋白向自噬泡的招募至关重要。Vps34因结 …
VPS34 K29/K48 branched ubiquitination governed by UBE3C and ... - Nature
2021年2月26日 · Here, we show that ubiquitin ligase UBE3C and deubiquitinating enzyme TRABID reciprocally regulate K29/K48-branched ubiquitination of VPS34. We find that this …
Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical ...
2018年9月20日 · Since full gene Vps34 KO causes early embryonic lethality 35, its role in vivo has been addressed by conditional inactivation in various lineages: myocytes 36, …
Dual Activity of Type III PI3K Kinase Vps34 is Critical for NK Cell ...
2024年3月27日 · Vps34 is the unique member of the class III phosphoinositide 3-kinase family that performs both vesicular transport and autophagy. Its role in natural killer (NK) cells …
ULK1-mediated metabolic reprogramming regulates Vps34 lipid
2023年6月2日 · In this study, we found that ULK1 activated lactate dehydrogenase A (LDHA) by phosphorylation to promote lactate production, then lactate-mediated Vps34 lactylation. …
Sci Adv | 华东理工大学团队报道Vps34乳酸化修饰调控细胞自噬
2023年6月2日， 华东理工大学程侠卫研究员、赵玉政教授以及杨弋教授 合作在 Science Advances 发表了题为“ ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity …
VPS34 Governs Oocyte Developmental Competence by …
2024年9月17日 · Vacuolar protein sorting 34 (VPS34) is renowned for its pivotal role in regulating autophagy and endocytic trafficking. To investigate its impact on oocyte development, oocyte …
VPS34 Acetylation Controls Its Lipid Kinase Activity and the …
Su et al. report a novel mechanism for the activity regulation of lipid kinase VPS34. The acetyltransferase p300-mediated acetylation inhibits VPS34 activity. Deacetylation of VPS34 …
Class III PI3K Vps34: essential roles in autophagy, endocytosis, and ...
Vps34 plays an essential role in the cellular process of autophagy, a process linked to human health and disease. Understanding the precise role of mammalian Vps34 will likely be integral …