Vps34是哺乳动物中的第III类PI3 Kinase（PIK3C3），磷酸化磷脂酰肌醇（PI）产生磷脂酰肌醇三磷酸（PI3P），这对于自噬泡膜的延伸和ATG蛋白向自噬泡的招募至关重要。Vps34因结合Vps15而被激活, 并进一步结合Beclin-1形成Vps34-Vps15-Beclin1复合物。

There is only one known class III PI 3-kinase, Vps34, which is also the only PI 3-kinase expressed in all eukaryotic cells. In humans it is encoded by the PIK3C3 gene. In human cells Vps34 associates with a regulatory subunit, PIK3R4 (p150, Vps15).

2023年6月2日， 华东理工大学程侠卫研究员、赵玉政教授以及杨弋教授 合作在 Science Advances 发表了题为“ ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation ”的研究成果。 该研究发现UNC-51样激酶1-ULK1在营养缺乏情况下促进LDHA磷酸化修饰增强其酶活性，进而促进乳酸生成。 乳酸在 乙酰基转移酶-TIP60 作用下介导III型磷脂酰肌醇激酶-Vps34蛋白发生乳酸化修饰，增强其脂质激酶活性，促进细胞自噬与溶酶体降解。 此 …

2021年3月10日 · VPS34 is the primordial member of the phosphoinositide 3-kinase (PI3K) family of lipid kinases, and it is present in all eukaryotic clades. It phosphorylates phosphatidylinositol (PI) to generate...

2017年11月27日 · Vps34 inhibition alters cellular energy metabolism, activating the AMPK pathway in liver and muscle. In liver, Vps34 inactivation mildly dampens autophagy, limiting substrate availability for...

2023年8月5日 · VPS34 is involved in regulating epidermal growth factor receptor (EGFR) nuclear translocation, which in turn promotes AKT/HK2 (protein kinase B/hexokinase Ⅱ)-regulated glycolysis. Simultaneous inhibition of autophagy and glycolysis by VPS34 results in a significant increase in the sensitivity of Osimertinib resistant cells to Osimertinib [33].

2023年5月8日 · vps34是自噬启动形成过程中的一个重要的蛋白激酶，因此受到广泛关注。 众所周知，VPS34是第三类磷脂酰肌醇3-激酶（PI3K）家族的独特成员，形成VPS34复合物1和复合物2，参与几个关键生理过程。

One family member, Vps34, is of particular interest because it is the only PI3-kinase identified in yeast and it has been evolutionarily conserved through mammals. Vps34 plays an essential role in the cellular process of autophagy, a process linked to human health and disease.

Su et al. report a novel mechanism for the activity regulation of lipid kinase VPS34. The acetyltransferase p300-mediated acetylation inhibits VPS34 activity. Deacetylation of VPS34 enhances VPS34-PI interaction and VPS34-Beclin 1 core complex formation. This p300-VPS34 pathway is critical to the initiation of canonical and non-canonical autophagy.

2017年10月13日 · 迄今的研究表明，vps34与其调控蛋白作用形成核心复合物是激活其活性的主要机制。 在题为“ VPS34 acetylation controls its lipid kinase activity and the initiation of canonical and non-canonical autophagy”...