VE-cadherin is a classical cadherin from the cadherin superfamily and the gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer.

血管内皮钙粘蛋白 (VE-cadherin)是II型经典钙粘蛋白家族细胞粘附蛋白的成员，介导血管内皮内的同质性粘附。 在连接细胞时，它们优先以亲和性的方式与自己相互作用；因此，钙粘蛋白可能有助于异质细胞类型的分类。 这种钙粘蛋白可能在内皮细胞生物学中发挥重要作用；它与α-连环蛋白结合，形成与细胞骨架的连接。 组织表达特异性：内皮组织和大脑。 定位于细胞连接处、细胞膜。 发现于细胞-细胞边界，也可能在细胞-基质边界。 KRIT1和CDH5相互调控它们在内皮细胞-细 …

Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule located at junctions between endothelial cells. In analogy of the role of E-cadherin as major determinant for epithelial cell contact integrity, VE-cadherin is of vital importance for the maintenance and control of endothelial cell contacts.

2017年12月20日 · Here, we show that VEGF-induced polarized cell elongation increases cell perimeter and decreases the relative VE-cadherin concentration at junctions, triggering polarized formation of actin-driven...

2015年4月23日 · In this study, Schwartz and colleagues set out to determine the specific role of the cell–cell junction protein VE-cadherin in flow signalling. They expressed chimaeras of …

The VeCAD (VLSI & Embedded Computing Architecture Design) research group focuses on domain-specific computing architecture, VLSI/SoC design, and embedded systems. In addition, the VeCAD group frequently collaborates with industry partners to ensure the research and teaching stay relevant with the latest technology trends and breakthroughs.

2017年11月10日 · VE-cadherin at endothelial cell-cell junctions links the contractile acto-myosin cytoskeletons of adjacent cells, serving as a tension-transducer. To explore tensile changes across...

篇首: 血管内皮钙黏蛋白 (VE-cadherin)是血管内皮细胞黏附连接的主要分子,是维持血管内皮细胞极性和完整性必不可少的内皮细胞特异性钙黏蛋白.随着 对钙黏蛋白的结构,功能及其影响因素的研究,以及其与其他黏附分子相互关系的分析,使得VE-cadherin在血管内皮细胞中的黏附作用以及在肿瘤血管 生成与转移中的作用日益明显.本文对其功能及其影响因素的研究进展以及在肿瘤中的用作做一综述. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研 …

2015年3月30日 · In summary, this study identifies a novel adapter function for VE-cadherin mediated by transmembrane domain association with VEGFRs. Endothelial responses to fluid shear stress are essential for vascular development and physiology, and determine the formation of atherosclerotic plaques at regions of disturbed flow.

血管内皮钙粘蛋白（VE-cadherin）是血管内皮细胞粘附连接的主要成分，是控制血管通透性的关键分子，在血管形成和毛细血管发生过程中起十分重要的作用，已成为研究毛细血管通透性和阻断肿瘤血管生长的重要靶点。