2025年3月30日 · VANGL2 (VANGL Planar Cell Polarity Protein 2) is a Protein Coding gene. Diseases associated with VANGL2 include Neural Tube Defects and Isolated Exencephaly. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Signaling by Rho GTPases. An important paralog of this gene is VANGL1.

2023年6月23日 · VANGL2 could be a potential clinical therapeutic target for viral infectious diseases, including COVID-19. Innate immunity is the critical first line of host defense against various pathogens, which requires complicated molecular …

The protein encoded by the VANGL2 gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets.

2021年7月26日 · Vangl2 directly binds to lysosome-associated membrane protein 2A (LAMP-2A) and targets it for degradation. MSC-specific Vangl2 ablation in mice increases LAMP-2A expression and CMA-lysosome numbers, promoting bone formation while reducing marrow fat.

2021年4月6日 · Here, we show that the planar cell polarity protein Vangl2 regulates the distribution of Wnt by cytonemes. In zebrafish epiblast cells, mouse intestinal telocytes and human gastric cancer cells,...

Van Gogh-like 2 (Vangl2)是平面细胞极性(planar cell polarity, PCP)通路的特异性关键组分，在极性的上皮细胞中定位于质膜。 本研究首次发现，在MSC中，Vangl2高度富集于CMA溶酶体膜的脂筏中，并促进CMA受体LAMP-2A的降解，从而自我限制此类溶酶体的CMA活性。...

Van Gogh‐like 2 (Vangl2) is a key PCP protein that is required for the normal differentiation of kidney glomeruli and tubules. Vangl2 has also been implicated in modifying the course of acquired glomerular disease, and here, we further explored how Vangl2 impacts on glomerular pathobiology in this context.

2025年2月8日 · Vangl2 suppresses NF-kappaB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation. Expression Profiles of ITGA8 and VANGL2 Are Altered in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT). Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations.

2017年10月20日 · Phospho-mutant Vangl2 exhibits dominant negative effects, whereas Vangl2 with reduced phosphorylation is hypomorphic. We show that Vangl2 phosphorylation is essential for its uniform...

2019年5月8日 · Our results demonstrate that VANGL2 is necessary for normal mammary gland development and indicate differential functional requirements in basal versus luminal mammary compartments. Recent...