Biochemistry, Very Low Density Lipoprotein - StatPearls - NCBI Bookshelf
Dec 4, 2022 · The synthesis and secretion of VLDL into circulation by the liver is a highly complex and regulated process that plays a fundamental role in the overall homeostasis of lipids in the body. Recent evidence has shown that the enhanced production and secretion of VLDL or alterations in its regulatory system directly contribute to developing ...
VLDL Biogenesis and Secretion: It Takes a Village
Jan 18, 2024 · Silencing of small valosin-containing protein-interacting protein (SVIP) reduces very low density lipoprotein (VLDL) secretion from rat hepatocytes by disrupting its endoplasmic reticulum (ER)-to-Golgi trafficking.
Unlocking the mysteries of VLDL: exploring its production ...
Inhibiting the secretion of hepatic VLDL lipids can effectively reduce the level of circulating lipids through three main pathways: (1) reducing the amount of lipids needed for VLDL assembly, (2) inhibiting the lipidation of VLDL in the liver, and (3) inhibiting the …
Intracellular Trafficking and Secretion of VLDL
May 1, 2012 · Understanding of molecular mechanisms and identification of factors regulating the complex intracellular VLDL trafficking will provide insight into the pathophysiology of various metabolic disorders associated with abnormal VLDL secretion and identify potential new therapeutic targets.
VLDL Biogenesis and Secretion: It Takes a Village - PubMed
Jan 19, 2024 · The production and secretion of VLDLs (very-low-density lipoproteins) by hepatocytes has a direct impact on liver fat content, as well as the concentrations of cholesterol and triglycerides in the circulation and thus affects …
The RNA-binding protein vigilin regulates VLDL secretion …
Sep 26, 2016 · By using in vivo, biochemical and genomic approaches, we demonstrate that vigilin controls very-low-density lipoprotein (VLDL) secretion through the modulation of apolipoproteinB/Apob mRNA ...
The regulation of hepatic fatty acid synthesis and ... - Nature
Sep 25, 2019 · Although secretion of VLDL 1 increases with increasing amounts of IHTAG 150, a limit to VLDL–TAG production seems to exist. Indeed, a plateau in secretion has been reported beyond 10% IHTAG...
Hepatic nonvesicular cholesterol transport is critical for systemic ...
Jan 16, 2023 · During fasting, adipose-tissue-derived fatty acids activate hepatocyte sphingomyelinase to liberate sequestered PM cholesterol. Aster-dependent cholesterol transport during fasting facilitates...
Intracellular trafficking and secretion of VLDL - PubMed
Understanding of molecular mechanisms and identification of factors regulating the complex intracellular VLDL trafficking will provide insight into the pathophysiology of various metabolic disorders associated with abnormal VLDL secretion and identify potential new therapeutic targets.
Overproduction of Very Low–Density Lipoproteins Is the Hallmark …
Jul 1, 2008 · Recent evidence suggests that a fundamental defect is an overproduction of large very low–density lipoprotein (VLDL) particles, which initiates a sequence of lipoprotein changes, resulting in higher levels of remnant particles, smaller LDL, and lower levels of high-density liporotein (HDL) cholesterol.