2022年3月22日 · Inner ear vestibular and spiral ganglion neurons (VGNs and SGNs) are known to play pivotal roles in balance control and sound detection. However, the molecular mechanisms underlying otic neurogenesis at early embryonic ages have remained unclear.

2020年1月8日 · Inner ear cochlear spiral ganglion neurons (SGNs) transmit sound information to the brainstem. Recent single cell RNA-Seq studies have revealed heterogeneities within SGNs. Nonetheless, much remains unknown about the transcriptome of SGNs, especially which genes are specifically expressed in SGNs.

2021年10月12日 · In both VGN and SGN, there is a significant correlation between resting potential and current threshold (p = 0.0003 in VGN, p = 0.0325 in SGN). Overall, larger stimulus currents are needed to induce spiking in transient-spiking neurons than in sustained-spiking neurons (compare the offset between the magenta and green regression lines in ...

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2023年8月1日 · Both vestibular ganglion neurons (VGNs) and spiral ganglion neurons (SGNs) were analyzed. VGNs and SGNs show manifest differences in their global gene profiles at E11.5. Two distinct VGN subtypes are detected first, but SGNs are homogeneous at E13.5.

2022年3月23日 · 内耳前庭神经节（VGN）和螺旋神经节（SGN）分别在维持机体平衡觉和感知声音信息过程中起关键作用，其损伤或退化可导致平衡障碍和耳聋。 其中，螺旋神经节对临床上人工耳蜗的疗效至关重要。

2021年10月12日 · Cell sizes were on average larger and more variable in VGN than in SGN. One sub-group of VGN stood out as having extra-large somata with transient-firing patterns, very low-input resistance, fast first-spike latencies, and required large current amplitudes to induce spiking.

2022年3月23日 · 内耳前庭神经节（VGN）和螺旋神经节（SGN）分别在维持机体平衡觉和感知声音信息过程中起关键作用，其损伤或退化可导致平衡障碍和耳聋。 其中，螺旋神经节对临床上人工耳蜗的疗效至关重要。 虽然成熟的内耳前庭神经节和螺旋神经节具有不同功能，但它们都起源于胚胎早期的耳囊神经母细胞，也被称作耳蜗前庭神经节前体细胞 (CVG)。 目前领域内有3个重要的问题亟待回答：1）耳蜗前庭神经节前体细胞是如何从耳囊中产生的？ 2）未分化的耳蜗前庭神 …

Here, we use single-cell RNA sequencing to reveal the transcriptomes of mouse otic tissues at three embryonic ages, embryonic day 9.5 (E9.5), E11.5, and E13.5, covering proliferating and undifferentiated otic neuroblasts and differentiating VGNs and SGN

2022年3月22日 · Inner ear vestibular and spiral ganglion neurons (VGNs and SGNs) are known to play pivotal roles in balance control and sound detection. However, the molecular mechanisms underlying otic neurogenesis at early embryonic ages have remained unclear.