VEGFR2，生物学术语，Vascular Endothelial Growth Factor Receptor 2（血管内皮细胞生长因子受体2）的英文简称，是VEGFR的亚型之一，又称FLK-1, 存在于血管和 淋巴管内皮 等处。 调节淋巴管内皮细胞和 血管内皮细胞，促进淋巴管和血管的生成，还有调节 淋巴细胞 的迁移等作用。 VEGFR2与 VEGF-C、VEGF-D结合，调节淋巴管内皮细胞和 血管内皮细胞，促进淋巴管和血管的生成，还有调节 淋巴细胞 的迁移等作用。

VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. [1] The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling.

VEGF调节肿瘤的血管生成，主要通过和其受体（VEGFR1、VEGFR2和VEGFR3）结合，从而激活细胞内信号通路； VEGF受体（VEGFR）的结构共有三个部分：细胞外的VEGF结合区，该区域由7个免疫球蛋白样结构构成；受体的跨膜区 (TM)；细胞内的信号传导结构域，包括酪氨酸激活结构。 VEGFR和VEGF蛋白结合后，其胞内信号转导区的酪氨酸随即发生磷酸化，从而激活细胞内信号通路，最终导致血管内皮细胞的生长、增殖和成熟，新生血管的生成。 VEGF-A和VEGFR …

2019年6月1日 · VEGFR-2/KDR is central and essential therapeutic target for the development of newer inhibitors as antiangiogenic agents. The prominent effect of KDR in cell proliferation, cell differentiation, migration, survival, angiogenesis, and lymph-angiogenesis support the choice of this receptor as a potential target for the discovery of novel inhibitors.

VEGFR-2 Is Involved in Regulating the Survival of Endothelial Cells. The VEGFR-2 plays crucial roles in vascular endothelial cell survival and blood vessel formation in vivo (Sase et al., 2009). VEGFR-2 regulates endothelial cell survival mainly by the activation of TSAd-Src-PI3K-PKB/AKT signaling pathway . Depending on VEGFR-2 and subsequent ...

VEGF-A regulates angiogenesis and vascular permeability by activating 2 receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk1 in mice). On the other hand, VEGF-C/VEGF-D and their receptor, VEGFR-3 (Flt-4), mainly regulate lymphangiogenesis.

VEGFR2 是VEGF (vascular endothelial growth factor，血管内皮生长因子)的细胞表面受体，在血管生成、血管发育、血管通透性和胚胎造血的调节中起着至关重要的作用。 VEGF与VEGFR2的结合会引发VEGFR2形成受体二聚体并活化下游信号通路。 VEGFR2的胞外区由7个类Ig亚基组成。 此外，VEGFR2还包括跨膜临膜结构域和催化酪氨酸激酶结构域。 图1. VEGF家族及其受体家族，VEGFR2受体活化及其下游功能 [1] 配体VEGF家族包括5个成员，分别是：VEGF-A、-B、 …

2003年6月1日 · VEGFR-2 undergoes dimerization and ligand-dependent tyrosine phosphorylation in intact cells and results in a mitogenic, chemotactic and prosurvival signal.

Vascular endothelial growth factor receptor-2 (VEGFR-2/KDR/Flk-1) is a high-affinity receptor for vascular endothelial growth factor-A (VEGF-A), and mediates most of the endothelial growth and survival signals from VEGF-A. VEGFR-2 has a typical tyrosine kinase receptor structure with seven immunoglo …

Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endotheli …