1995年5月12日 · Four vascular endothelial growth factor (VEGF) splice variants containing 121, 165, 189, and 206 amino acids are produced from a single human gene as a result of alternative splicing. VEGF121 is not a heparin-binding protein, while the other VEGF species possess heparin binding ability.

2016年4月1日 · Here we measure the expression of VEGF165 and VEGF121 in human cancer and their influence on tumor growth and vascularization.

2003年12月1日 · Vascular endothelial growth factor (VEGF) is essential for the induction of angiogenesis and drives both endothelial cell (EC) proliferation and migration. It has been suggested that VEGF...

Four vascular endothelial growth factor (VEGF) splice variants containing 121, 165, 189, and 206 amino acids are produced from a single human gene as a result of alternative splicing. VEGF 121 is not a heparin-binding protein, while the other VEGF species possess heparin binding ability.

We measured the expression levels of VEGF165 and VEGF121 in human colorectal cancer and found that VEGF121 was more expressed than VEGF165, particularly in patients with extensive lymph node infiltration.

2017年10月10日 · VEGF121 expression level has a major impact on survival of patients with refractory/relapsed ABC-like DLBCL and is strongly associated with an immune response. This immune response signature is well-conserved in all cancer subtypes and may lead to new therapeutic perspectives.

Vascular endothelial growth factor A (VEGF) is one of the major regulators of angiogenesis. It plays an important role during the process of physiological and pathological neovascularization. Variant VEGF isoforms are generated as a result of alternative pre-mRNA splicing.

2007年6月6日 · Cohen T. , Gitay-Goren H. , Sharon R. , Shibuya M. , Halaban R. , Levi B.Z. , Neufeld G. VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells.

2011年7月6日 · The vascular endothelial growth factor A isoform 121 (VEGF121)-gelonin fusion protein (VEGF121/rGel)–conjugated manganese ferrite (MnFe2O4) nanoparticle (NP), abbreviated as VEGF121/rGel-MNP, is a VEGF receptor (VEGFR)-targeted contrast agent developed by Cho et al. for monitoring the targeting efficiency and treatment efficacy of the …

2017年10月13日 · Vascular endothelial growth factor (VEGF)mRNA undergoes alternative splicing events that generate four different homodimeric isoforms, VEGF121, VEGF165, VEGF189, or VEGF206. VEGF121 is a nonheparin-binding acidic …