Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. [5] VCAM-1 functions as a cell adhesion molecule.

VCAM-1 is a key cell adhesion molecule involved in inflammation that is closely implicated in various immunological disorders, including rheumatoid arthritis, asthma, transplant rejection, and cancer . VCAM-1 is a potential therapeutic target in immunological disorders and cancer.

2023年7月15日 · Intercellular adhesion molecule 1 (ICAM-1) and Vascular cell adhesion molecule 1 (VCAM-1) belong to the immunoglobulin superfamily of cell adhesion molecules (CAM) with a crucial role in mediating the strong adherence of leukocytes to endothelial cells in numerous acute as well as chronic diseases.

2025年3月30日 · Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include integrin binding and primary methylamine oxidase activity .

2023年5月13日 · We found that VCAM-1 via JunB regulates IL-8 promoter activity and expression in human retinal endothelial cells.

VCAM-1 expression is upregulated by CD34+/CD133+-stem cells derived from septic patients; Circulating soluble vascular cell adhesion molecule (VCAM-1) level was a useful diagnostic parameter for understanding the difference between coronary artery disease (CAD) and cardiac syndrome X (CSX).

VCAM-1 is a cell surface receptor expressed on activated mesothelial and endothelial cells. It functions in regulation of leukocyte attachment and extravasation at sites of inflammation [12,132]. VCAM-1 is preferentially expressed on mesothelium of ovarian cancer and contributes to mesothelial migration.

2023年8月1日 · Vascular inflammation is aided by ICAM-1 and VCAM-1. VCAM-1 is shed by metalloproteinases, which cause VCAM-1 to become soluble. VCAM-1 in soluble form forecasts cardiovascular morbidity and mortality. Atrial fibrillation development and maintenance are predicted by soluble VCAM-1.

There is emerging evidence that VCAM-1 is more than a biomarker and may be a promising therapeutic target for vascular diseases. While there are neutralizing antibodies that allow preclinical research, the development of pharmacological tools to activate or inhibit this protein are required to thoro …

2018年11月19日 · We identify a VCAM-1+ macrophage-like niche cell population that patrols the inner surface of the venous plexus, interacts with HSPCs in an ITGA4-dependent manner, and directs HSPC...