2022年10月6日 · Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3 (AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic properties. VAP-1 is a primary amine oxidase belonging to the semicarbazide-sensitive amine oxidase (SSAO) family, which catalyzes the oxidation of primary amines leading to the ...

2022年10月6日 · VAP-1 是一种伯胺氧化酶，属于氨基脲敏感型胺氧化酶 (SSAO) 家族，可催化 伯胺的氧化，从而产生铵、甲醛、甲基乙二醛和过氧化氢。 VAP-1主要由内皮细胞、平滑肌细胞、脂肪细胞和周细胞表达。 它涉及一系列生物学功能，例如免疫细胞外渗、血管生成和血管化。 在过去的十年中，VAP-1 的研究已经加强，因为它作为一种新的临床生物标志物和作为血管炎性疾病（如动脉粥样硬化、中风、糖尿病、神经血管疾病（例如阿尔茨海默病）、肝病（例如非酒精 …

Vascular adhesion protein 1 (VAP-1) is a nonclassical inflammation-inducible endothelial molecule involved in leukocyte-subtype-specific rolling under physiological shear. Molecularly, VAP-1 belongs to a special class of cell surface amino oxidases.

2001年4月1日 · Vascular adhesion protein 1 (VAP-1) is a nonclassical inflammation-inducible endothelial molecule involved in leukocyte-subtype-specific rolling under physiological shear. Molecularly, VAP-1 belongs to a special class of cell surface amino oxidases.

2000年6月23日 · Human vascular adhesion protein-1 (VAP-1) is an endothelial glycoprotein involved in this interaction. It also displays an enzymatic (monoamine oxidase) activity. Here we examined how recombinant human VAP-1 mediates lymphocyte binding using rotatory and flow chamber binding assays.

2021年7月7日 · Vascular adhesion protein-1 (VAP-1) is a semicarbazide-sensitive amine oxidase (SSAO), whose enzymatic activity regulates the adhesion/exudation of leukocytes in/from blood vessels.

2013年6月15日 · VAP-1 is a 180 kD glycoprotein also known as semicarbazide-sensitive amine oxidase (SSAO) or copper-containing amine oxidase (AOC 3, EC 1.4.3.6) that catalyzes oxidative deamination of primary amines. The enzymatic function has been studied using non-physiological substrates such as benzylamine.

2021年7月8日 · Vascular adhesion protein-1 (VAP-1) is a semicarbazide-sensitive amine oxidase (SSAO), whose enzymatic activity regulates the adhesion/exudation of leukocytes in/from blood vessels. Due to its abundant expressions in vascular systems and prominent roles in inflammations, increasing attentions have b …

2022年10月6日 · Research into VAP-1 has intensified within the last decade on its role as a novel clinical biomarker and as a potential therapeutic target of vascular inflammatory disorders such as atherosclerosis, stroke, diabetes, neurovascular disorders (e.g., Alzheimer’s Disease), hepatic disease (e.g., non-alcoholic steatohepatitis), and skin conditions ...

血管黏附蛋白1 (VAP-1)是一种在哺乳动物体内广泛存在的多功能蛋白.VAP-1既是一种黏附分子,又是一种胞外酶,其在白细胞渗出、黏附级联反应、糖代谢调节、血管损伤等方面都发挥了重要的作用.在炎症性疾病、糖代谢相关疾病、肿瘤、脑卒中等众多临床疾病中,VAP-1的表达及功能都有着重要的意义,而使用VAP-1抗体和抑制剂已经在许多临床疾病的动物模型上显示了显著的治疗作用.