2025年3月30日 · USP36 (Ubiquitin Specific Peptidase 36) is a Protein Coding gene. Diseases associated with USP36 include Machado-Joseph Disease. Among its related pathways is Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include RNA binding and cysteine-type deubiquitinase activity.

2014年1月26日 · 美国药典-国家处方集每年出版一次，目前已经出版到第36版（USP36 - NF 31 2012年12月份出版）。 每一版本的《美国药典》包含3卷及2个增补版。 美国药典除了印刷版外，还提供U盘版和互联网在线版。 美国药典-国家处方集（USP-NF）是两个法定药品标准：美国药典 (USP) 和国家处方集 (NF) 的三卷合订本。 USP 中提供关于原料药和制剂的质量标准。 关于食物补充剂和成份的质量标准在 USP 中以独立章节予以收载。 NF 中提供关于辅料的质量标准 …

2023年10月13日 · USP36 is transcriptionally upregulated through the JNK-HSF1 axis upon ribotoxic stress, and functions as a nucleolar deubiquitinase to stabilize Snail1 protein. A combination of HHT with...

Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene. [5] [6] This gene encodes a member of the ubiquitin-specific protease family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the nucleoli and deubiquitinate nucleophosmin and fibrillarin [7]

该基因编码肽酶 C19 或半胱氨酸蛋白酶泛素特异性蛋白酶家族的成员。 该家族的成员从多泛素化蛋白质中去除泛素分子。 编码的蛋白质可以去泛素化并稳定转录因子 c-Myc，也称为 MYC，这是一种已知在大多数人类癌症中上调的重要癌蛋白。 编码的蛋白酶还可以调节自噬的激活。 该基因在某些乳腺癌和肺癌中表现出升高的表达。 [RefSeq 提供，2016 年 3 月] This gene encodes a member of the peptidase C19 or Ubiquitin-Specific Protease family of cysteine proteases.

2024年9月29日 · Ubiquitin-specific protease 36 (USP36), belonging to the deubiquitinating enzyme family, is involved in tumor progression across multiple cancers. However, the...

2023年7月13日 · Crystal structures of USP36 complexed with Fubi and ubiquitin uncover its substrate recognition mechanism and explain how other deubiquitinases are restricted from Fubi. Furthermore, we introduce...

The deubiquitinating enzyme, ubiquitin-specific protease 36 (USP36), a member of the USP family, plays a crucial role in this dynamic equilibrium by hydrolyzing and removing ubiquitin chains from target proteins and facilitating their proteasome-dependent degradation.

2024年5月12日 · The deubiquitinating enzyme, ubiquitin-specific protease 36 (USP36), a member of the USP family, plays a crucial role in this dynamic equilibrium by hydrolyzing and removing ubiquitin chains from target proteins and facilitating their proteasome-dependent degradation.

2025年2月9日 · USP36 overexpression stabilized c-Myc and SOD2 by preventing ischemia-induced ubiquitination of both proteins. USP36 regulates PME-1 as a DUB and participates in the ERK and Akt signaling pathways; Together, our results reveal USP36 as a novel H2B deubiquitinase and shed light on its additional functions in regulating gene expression.