2012年11月28日 · Urine cytology is an important test in the investigation of patients who are at risk for urothelial carcinoma (UroCA) and in the surveillance of patients with UroCA, a common cancer of adults with significant mortality.

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2018年9月1日 · Urine cytology (UC) is used in surveillance of patients with a history of urothelial carcinoma (UroCa) of the bladder. UroVysion fluorescent in situ hybridization (FISH) was introduced as a more sensitive method for monitoring disease recurrence.

2018年6月21日 · Urine cytology specimens are essential for screening and monitoring high-grade urothelial carcinomas. However, inconsistent reporting and equivocal diagnostic categories have remained a challenge. The Paris System for Reporting Urinary Cytology (TPS) was developed to provide clear cytomorphologic criteria for urine cytology specimens.

2011年5月31日 · In contrast to benign bladder, urothelial carcinomas (UroCa) show constitutive SOX9 induction through autonomous EGFR activation, and SOX9 was significantly upregulated in invasive carcinomas. SOX9 knockdown significantly impaired UroCa cell migration and invasion, suggesting its role in UroCa pathogenesis.

High-throughput drug screening, using a library comprising 1567 compounds in SarBC-01 and conventional urothelial carcinoma (UroCa) organoids, identified drug candidates active against SARC cells...

Upper tract urothelial carcinomas (UTUCs) are rare entities that are usually diagnosed at advanced stages. Research on UTUC pathobiology and clinical management has been hampered by the lack of models accurately reflecting disease nature and diversity.

2011年6月1日 · Like many carcinomas, urothelial carcinoma (UroCa) is associated with chronic injury. A better understanding of this association could inform improved strategies for preventing and treating this disease. We investigated the expression, regulation, and function of the transcriptional regulator SRY-re …

The recent identification of urothelial differentiation programs in urothelial carcinomas (UroCas) supports the idea that solid epithelial cancers (carcinomas) develop and differentiate analogously to normal epithelia and provides new insights about the spatial localization and molecular makeup of carcinoma CSCs.

2023年11月2日 · Sarcomatoid Urothelial Bladder Cancer (SARC) is a rare and aggressive histological subtype of bladder cancer for which therapeutic options are limited and experimental models are lacking. Here, we report the establishment of a long-term 3D organoid-like model derived from a SARC patient (SarBC-01).