ULK 是自噬信号通路唯一一个具有丝氨酸/苏氨酸激酶活性的核心蛋白。 在自噬溶酶体组装前自噬信号是通过由 ULK1 或 ULK2、FIP200 和 mATG13 组成的 ULK 复合物 的活化介导的。 ULK1 复合物在体内是连接上游营养或能量感受器 mTOR 和 AMPK 与下游自噬体形成的桥梁。

2025年3月30日 · ULK2 (Unc-51 Like Autophagy Activating Kinase 2) is a Protein Coding gene. Diseases associated with ULK2 include Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7 and Parkinson's Disease. Among its related pathways are Autophagy and Alzheimer's disease and miRNA effects.

Unc-51-like kinase 2 (C. elegans) also known as ULK2 is an enzyme which in humans is encoded by the ULK2 gene. [1] The gene is located within the Smith–Magenis syndrome region on chromosome 17.

ULK1、 ULK2 与一种自噬相关 (Atg) 基因产物 (mAtg13) 的哺乳动物同源体，以及骨架蛋白 FIP200（与酵母 Atg17 直接同源）共同形成一个较大的复合体。

2020年7月2日 · Macroautophagy is initiated primarily by a complex containing ULK1 or ULK2 (two paralogs of the yeast Atg1 protein). To understand the differences between ULK1 and ULK2, we compared the human...

Altogether, our results indicate that skeletal muscle ULK2 has a unique role in basal selective protein degradation by stimulating the recognition and proteolytic sequestration of insoluble ubiquitinated protein aggregates associated with p62 and NBR1.

2011年10月24日 · Vertebrates in contrast have at least five different kinases closely related to Atg1 in their N-terminal kinase domain. The most highly related unc-51-like kinase 1 (Ulk1) and Ulk2 were first identified as close homologs of C. elegans uncoordinated-51 (unc-51), showing 78% amino acid identity in their catalytic domains (61, 103, 112, 113).

ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia. An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.

2016年6月2日 · In mammals Unc51-like autophagy activating kinase 1 (ULK1) and ULK2 are the major inducers of autophagy, and thus their depletion from the brain would be expected to …

中文名称：unc-51 样自噬激活激酶 2 种属: Homo sapiens 同用名: ATG1B; Unc51.2