2011年3月28日 · Recently GPR92/LPA5 was identified as an LPA receptor highly expressed by cells of the immune system, which prompted us to investigate its presence and influence on …

2018年1月1日 · To search for potent LPA5 antagonists with blood brain barrier (BBB) permeability, we conducted high throughput screening (HTS). In HTS campaign, we found a …

2011年3月28日 · Recently GPR92/LPA5 was identified as an LPA receptor highly expressed by cells of the immune system, which prompted us to investigate its presence and influence on …

2025年1月4日 · LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling. LPAR5 expression was elevated in A375cells treated …

In mouse and human microglia, LPA 5 belongs to a set of receptors that cooperatively detect danger signals in the brain. Engagement of LPA 5 by LPA polarizes microglia toward a pro …

This review provides an in-depth discussion of LPAR5, which has recently emerged as a key player in regulating normal intestinal homeostasis and modulating pathological conditions such …

In this report, we characterize specific TCR signaling pathways that are suppressed by LPA 5 in both mouse and human CD8 T cells and demonstrate that a crucial outcome of this inhibition …

2023年5月1日 · In this review, we provide a brief overview of the pathways that regulate LPA production and degradation, followed by an in-depth discussion on the LPAR subtype 5 …

2019年11月29日 · Under neuro-inflammatory conditions signaling along the LPA/LPAR5 axis induces a potentially neurotoxic microglia phenotype indicating the need for new …

2018年1月1日 · To search for potent LPA5 antagonists with blood brain barrier (BBB) permeability, we conducted high throughput screening (HTS). In HTS campaign, we found a 2 …