Uridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a microsomal glycosyltransferase (EC 2.4.1.17) that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule.

yltransferase, UGT)属于糖基转移酶一号家族(GT family 1), 主要以植物中最常见的尿苷二磷酸(UDP)-糖 类为活化糖基分子供体, 以类黄酮、酚酸、萜类以及植物激素等小分子化合物为糖基受体。

2016年1月1日 · UGT-catalyzed conjugation of small lipophilic compounds with sugars is an important detoxification and homeostatic function in all living organisms. The UGT superfamily is defined by a common protein structure and signature sequence of 44 amino acids responsible for binding the UDP moiety of the sugar donor [1], [2].

2013年6月1日 · Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of the UGT1A and 2B subfamilies play a key role in terminating the biological actions and enhancing the renal elimination of non-polar (lipophilic) drugs from all ...

2015年2月1日 · UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze the transfer of glucuronic acid to hydroxyl, carboxyl, or amine groups of compounds, whereas esterases hydrolyze compounds that contain ester, amide, and thioester bonds.

摘要: UDP-glucuronosyltransferases (UGTs) are important phase II metabolic enzymes responsible for approximately 40-70% of endo and xenobiotic reactions. It catalyzes the transfer of glucuronic acid to lipophilic substrates, converting them …

udp-葡萄糖醛酸转移酶是一种结合在内质网上的膜蛋白。 它在把葡萄糖醛酸从UDP-葡萄糖醛酸 UDP-glucuronic acid (UDPGA) 转移到其他分子（通常是疏水分子）上的过程中起到催化作用。

UDP-glucuronosyltransferases (UGTs) are the primary phase II enzymes catalyzing the conjugation of glucuronic acid to the xenobiotics with polar groups for facilitating their clearance. The UGTs belong to a superfamily that consists of diverse isoforms possessing distinct but overlapping metabolic a …

2019年4月1日 · UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad range of exogenous chemicals and by-products of endogenous metabolism, and also controls the levels and distributi …

植物尿苷二磷酸糖基转移酶 (uridine diphosphate glycosyltransferase,UGT)属于糖基转移酶一号家族 (GT family 1),主要以植物中最常见的尿苷二磷酸 (UDP)-糖类为活化糖基分子供体,以类黄酮、酚酸、萜类以及植物激素等小分子化合物为糖基受体。 由于UGT催化的底物种类繁多,产物活性差异较大,其催化的糖基化反应在植物生长发育及代谢调节过程中具有十分重要的作用。 本文概述了植物UGT家族的蛋白结构、特征及催化底物的相关信息,由UGT参与植物的次生代谢、激素调控 …