ER stress activates a signaling network called the Unfolded Protein Response (UPR) to alleviate this stress and restore ER homeostasis, promoting cell survival and adaptation. However, under unresolvable ER stress conditions, the UPR promotes apoptosis.

2025年1月10日 · We found that adenosine 3′,5′-monophosphate response element–binding protein 3–like protein 2 (CREB3L2), a noncanonical UPR factor, is overexpressed and activated in triple-negative breast cancer, where its cleavage releases a C-terminal fragment that activates the Hedgehog pathway in neighboring CD8+ T cells.

2018年10月15日 · We now report that Unfolded Protein Response (UPR), autophagy, and apoptosis related genes cluster separately during lactation and involution in the mouse mammary gland....

19 小时之前 · The unfolded protein response (UPR), a cellular mechanism activated during endoplasmic reticulum (ER) ... IHC and TUNEL staining. Tumor tissue samples were fixed, embedded, sectioned (3 μm ...

2024年12月19日 · 本研究发现，在环境温度升高至25°C时，秀丽隐杆线虫（C. elegans）的ER UPR被激活（线虫的适宜生存温度范围为 15°C-25°C），内质网（ER）的形态发生改变，进而通过PMK-1/p38启动免疫反应。 利用RNA干扰（RNAi）敲低ER UPR的相关基因（如xbp-1, ire-1, pek-1），高温提升的免疫反应被显著削弱，表明ER...

We will discuss evidence for UPR activation in neurodegenerative diseases, and the methodology to study UPR activation and its connection to brain pathology will be addressed. More recently, the UPR is recognized as a target for drug therapy for treatment and prevention of neurodegeneration, by inhibiting the function of specific mediators of ...

Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and activate a set of signaling pathways termed the Unfolded Protein Response (UPR). The UPR can promote cellular repair and sustained survival by reducing the load of unfolded proteins through upregulation of chaperones and global ...

UPR promotes cellular survival in response to stress in three ways: (i) blocking of protein translation for restoring homeostasis; (ii) positive regulation of protein folding related molecular chaperones; and (iii) up-regulation of signaling responsible for targeting mis-/un-folded proteins in ER for ubiquitination mediated degradation.

2017年9月1日 · The UPR aims to restore the ER-associated protein folding capacity by increasing ER volume and expression of ER-associated chaperones, as well as (transiently) attenuating global protein translation. In mammalian cells, the UPR is governed by three ER stress sensors, namely, inositol-requiring enzyme 1 alpha (IRE1α), protein kinase R-like ER ...

Using IHC techniques on sections serial to the ones used to identify UPR markers, we detected evidence of infection by EBV, CMV, and KSHV in the lungs of the IPF patients in which we had ...