子宫自然杀伤细胞(uterine natural killer cells, uNK)作为先天免疫系统的一员,约占妊娠期淋巴细胞总数的70%,在对宿主免受病原体侵袭方面起着重要作用,并参与了一系列影响妊娠成功的生理过程。 能通过分泌多种细胞因子,促进滋养层侵袭,重塑螺旋动脉,保护胎儿发育,维持正常妊娠。 而失衡的uNK细胞会导致螺旋动脉重构不足和滋养层入侵受损,并与产科并发症如子痫前期、复发性流产、胎儿生长受限密切相关。 本篇综述对uNK 细胞及其uNK细胞在生理或病理条件下对妊娠的作用 …

Uterine natural killer (uNK) cells are an immune subset located in the uterus. uNK cells have distinct tissue-specific characteristics compared to their counterparts in peripheral blood and lymphoid organs.

2019年4月30日 · During pregnancy, NK cells are the most abundant lymphocytes in the uterus at the maternal-fetal interface and are involved in placental vascular remodeling. Prior studies suggested that these uterine NK (uNK) cells are mostly derived from circulating NK cells.

2018年12月1日 · In response to embryo implantation, the uterus remodels with maternal immune cells occupying the maternal-fetal interface and uterine natural killer (uNK) cells becoming the most prominent leukocyte. Recently, uNK cells have been discovered to be heterogeneous, including conventional NK and tissue-resident NK cells.

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2023年3月23日 · The uNK cells accumulate in the decidua until week 20 of gestation, with the highest numbers present in early pregnancy. uNK cells play a unique role in decidualization and trophoblast implantation, and uNK cells have been suggested to be remarkably different from other subsets of CD56 bright NK cells in peripheral blood ( 4 – 10 ).

Uterine natural killer (uNK) cells, sharing many characters with peripheral blood natural killer (pNK) cells, are a major uterine lymphocyte population at early gestational stages during normal pregnancy in placental mammals. The functions of uNK cells include cytokine production and cytotoxicity th …

2017年9月6日 · Uterine natural killer (uNK) cells are short-lived, terminally differentiated and the most abundant lymphocytes in the uterus which play a crucial role in the spiral arteriole modification and establishment of successful pregnancy.

2025年1月27日 · Rapper DJ Unk, who was best known for the bouncy early-2000s crunk hit “Walk It Out,” has died. The musician’s wife Sherkita Long-Platt announced his death Friday morning on Facebook.

2025年1月31日 · Artikel ini akan mengupas tuntas berbagai informasi mengenai kematian DJ Unk, mulai dari laporan resmi hingga spekulasi yang beredar di masyarakat. Kita akan menelusuri jejak karirnya, menganalisa faktor-faktor yang mungkin berkontribusi pada kematiannya, dan melihat dampak kepergiannya bagi industri musik.