Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene. [5] [6] Unc-51-like autophagy-activating kinases 1 and 2 (ULK1/2) are two similar isoforms of …

2025年3月30日 · ULK1 (Unc-51 Like Autophagy Activating Kinase 1) is a Protein Coding gene. Diseases associated with ULK1 include Overnutrition and Neurodegeneration With Brain Iron …

The ULK1 complex initiates autophagosome formation, linking cellular nutrient status to downstream events in autophagy. Recent work suggests that the ULK1 complex might also be …

The ULK1 complex consists of ULK1, FIP200, ATG13 and ATG101 and regulates initiation of autophagosome formation. Lack of one or more ULK1 complex components results in …

2021年10月15日 · Here we show that ULK1 phosphorylates the BNIP3 mitochondrial cargo receptor on a critical serine residue (S17) adjacent to its amino terminal LIR motif. ULK1 …

2018年8月9日 · UNC-51-like kinase 1 (ULK1), known as an ortholog of the yeast Atg1, is the serine-threonine kinase and the autophagic initiator in mammals. Accumulating evidence has …

ULK1 is a hypoxia regulated gene and is associated with hypoxia tolerance and a worse clinical outcome. ULK1 complex forms puncta associated with the ER and sporadically with …

2024年11月27日 · Title: SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy. Inhibition of ULK1/2 and …

The human serine/threonine kinase ULK1 is the human homolog of the Caenorhabditis elegans Unc-51 kinase and of the Saccharomyces cerevisiae autophagy-related protein kinase Atg1. …

1 天前 · Furthermore, we found that XN induced mitophagy and exerted anti-OS effects through the activation of the AMPK-ULK1-FUNDC1 signaling pathway, which was effectively reversed …