2025年3月30日 · UHRF1 (Ubiquitin Like With PHD And Ring Finger Domains 1) is a Protein Coding gene. Diseases associated with UHRF1 include Immunodeficiency-Centromeric …

Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene. [5][6] This gene encodes a member of a …

2024年12月26日 · uhrf1的主要功能是调控dna甲基化和组蛋白修饰，这两个过程对基因的表达调控至关重要。 具体来说，UHRF1通过识别和结合甲基化的DNA和特定的组蛋白修饰，帮助维持 …

UHRF1 is a master regulator of epigenome as it coordinates DNA methylation and histone modifications. Compelling evidence suggests a strong link between UHRF1 overexpression …

2013年3月5日 · Epigenetic inheritance of DNA methylation in mammals requires a multifunctional protein UHRF1, which is believed to recruit DNMT1 to DNA replication forks through a unique …

UHRF1 is an important epigenetic regulator maintaining DNA methylation and histone code in the cell. It is highly expressed in a variety of cancers and is a well-known oncogene that can …

2025年2月9日 · UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma. Interfering with the Expression of Ubiquitin-Like with PHD and Ring Finger Domains 1 Can …

2024年4月5日 · DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1 functions …

In this review, we summarize the current knowledge on the molecular function of the UHRF family in various biological pathways and discuss their roles in epigenetics, development, …

2021年9月24日 · Here we report that UHRF1, an epigenetic regulator highly expressed in proliferating and cancer cells, interacts with AMPK and serves to suppress AMPK activity …