UCH-L3 structure and function: Insights about a promising …
2022年1月5日 · This structure reveals a model of UCH-L3 enzyme isolated with ubiquitin vinyl methyl ester (UbVME) which is an inhibitor that forms a covalent adduct with the catalytic …
UCHL3 - Wikipedia
Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene. [5][6] UCHL3 has been shown to interact with NEDD8 and the tauopathy and …
UCH-L3 结构和功能：关于有前景的药物靶点的 ... - X-MOL
在这篇综述中，我们概述了 UCH-L3 催化机制、结构、其在 DNA 修复和癌症中的作用以及迄今为止发现的阻止其活性的抑制剂。 不言而喻，它表现在保持健康和疾病异常调节时。 由于它是 …
UCHL3 Gene - GeneCards | UCHL3 Protein | UCHL3 Antibody
2025年3月30日 · UCHL3 (Ubiquitin C-Terminal Hydrolase L3) is a Protein Coding gene. Diseases associated with UCHL3 include Machado-Joseph Disease and Autosomal Dominant …
Role of UCHL3 in health and disease - ScienceDirect
2024年11月19日 · Ubiquitin C-terminal hydrolase 3 (UCHL3) is a cysteine protease that plays a crucial role in cell cycle regulation, DNA repair, and apoptosis by carrying out deubiquitination …
UCHL3人源基因|UCHL3基因突变_致病性_靶点-RDDC官网
Ubiquitin dimers control the hydrolase activity of UCH-L3. Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses. Mutant ubiquitin …
泛素 C 端水解酶 L3（UCHL3）基因 | MCE - MCE-生物活性 ...
泛素 c 端水解酶 l3： 该基因编码的蛋白质是去泛素化酶家族的成员。 该家族的成员是催化从多肽中去除泛素的蛋白酶，根据催化机制分为五类。 这种蛋白质可以水解泛素化蛋白质的泛素基 …
UCH-L3 structure and function: Insights about a promising drug …
2022年1月5日 · In this review we present an overview of UCH-L3 catalytic mechanism, structure, its role in DNA repair and cancer along with the inhibitors discovered so far to halt its activity. …
UCHL3 ubiquitin C-terminal hydrolase L3 [ (human)]
UCH-L3 is a novel regulator of epithelial-mesenchymal transition and cell migration in prostate cancer cells. Data identified of UCHL3 as an essential deubiquitinase in adipogenesis. …
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and ... - PubMed
2014年9月26日 · Ubiquitin C-terminal hydrolase-L3 (UCH-L3) is among the deubiquitinating enzymes (DUBs) that cleave ubiquitin (Ub) from Ub precursors or protein substrates. Many …