Concepts of extracellular matrix remodelling in tumour ... - Nature
2020年10月9日 · Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour …
Extracellular matrix and its therapeutic potential for cancer …
2021年4月23日 · During tumorigenesis, the interplay between cancer cells and the tumor microenvironment (TME) often results in the stiffness of the ECM, leading to aberrant …
The Interplay between Extracellular Matrix Remodeling and Cancer ...
While the ECM may protect tumors from anti-cancer agents, recent research highlights the paradoxical role of therapy-induced ECM remodeling in promoting treatment resistance and …
The extracellular matrix as hallmark of cancer and metastasis
2024年1月3日 · Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate …
Modulating extracellular matrix stiffness: a strategic approach to ...
ECM stiffness forms a formidable physical barrier around tumors, hindering immune cell infiltration and impeding the precise delivery of immunotherapeutic agents. 1. What is the role of ECM...
Extracellular Matrix in the Tumor Microenvironment and Its …
Understanding the particularities of the ECM in solid tumor is necessary to develop approaches to interfere with its negative effect. In this review, we will also highlight the current understanding …
Unraveling the Role of the Tumor Extracellular Matrix to Inform ...
2024年12月4日 · Through restoring the ECM to healthy-like conditions, this treatment aims to improve tissue perfusion, facilitating the delivery of chemotherapies. In particular, the …
Extracellular matrix in cancer progression and therapy - PMC
We highlight that the biomolecular, biophysical, and mechanochemical interactions between the ECM and cells not only regulate the steps of cancer progression, but also affect the efficacy of …
Extracellular matrix remodeling in tumor progression and immune …
2023年3月11日 · In this paper, we discuss the key role of ECM remodeling in the TME and its interaction with tumor cells, including the molecular composition of ECM and the impact of …
The extracellular matrix in solid tumor immunotherapy - Cell Press
2024年8月19日 · The extracellular matrix (ECM) of solid tumors impacts the antitumor activities of CD8+ T and natural killer (NK) cells in a variety of ways. Cell motility is restricted by the tumor …